Biological significance of the duplicated GGAA-motifs in the human TATA-less gene promoters
| Project/Area Number |
24510270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Research Collaborator |
TANUMA Sei-ichi 東京理科大学, 薬学部・薬学科, 教授
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 転写制御 / GGAA / ISG / OAS1 / ELF-1 / TP53 / HELB / ETS / ELF1 / 転写因子 / インターフェロン応答 / DNA修復 / ミトコンドリア関連 / 細胞老化 / TATA-less promoter / mitochondria / interferon / DNA-reapir |
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| Outline of Final Research Achievements |
In this study, it was revealed that anti-viral factor encoding OAS1 gene is up-regulated by ELF-1, suggesting a new therapeutic method for leukemia introducing the transcription factor encoding gene(s) into cells. Moreover, it was shown that a natural compound resveratrol affects duplicated GGAA-motifs to activate promoter activities of the human TP53 and HELB genes, which encode tumor suppressor p53 and G1/S transition regulatory DNA helicase, respectively. The results suggest that natural product or introduction of specific genes into cells could be applied for cancer treatment up-regulating DNA-repair system at a transcriptional level. On the basis of these observations, we have started to investigate promoter regions of the human mitochondrial-function or DNA-repair associated genes analyzing their responses to various anti-tumor/anti-aging drugs.
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Report
(5 results)
Research Products
(87 results)
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[Journal Article] A new protocol to discover novel anti-aging compounds2012
Author(s)
F. Uchiumi, T. Oyama, K. Ozaki, M. Fukui, H. Ogawa, Y. Sasaki, H. Tachibana, C. Fukushima, M. Fujikawa, H. Abe, S. Larsen, S. Tanuma
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Journal Title
Pharm. Anal. Acta.
Volume: 3
Pages: 166-166
Related Report
Peer Reviewed
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[Book] DNA Repair2015
Author(s)
Fumiaki Uchiumi, Steven Larsen, Sei-ichi Tanuma
Publisher
InTech-Open Access Publisher, Inc.
Related Report
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