| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
The budding yeast Saccharomyces cerevisiae is one of the most important model organisms for studying cellular senescence and lifespan. Haploid cells of the yeast is convenient for analyzing gene function. In this study, we have investigated yeast diploid cells as a better model for cellular lifespan study since higher organisms are generally diploid cells. Diploid cells of wild-type strain exhibited longer replicative lifespan, the number of cells produced from a cell before dying, than haploid cells. During searching genes that are specifically expressed in diploid cells, we found novel longevity genes. Using heterozygous diploid knockout mutants, we discovered novel longevity genes essential for cell proliferation.
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