Searching for novel compounds from the nematocysts.
Project/Area Number |
24510294
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Tokyo University of Marine Science and Technology |
Principal Investigator |
NAGAI Hiroshi 東京海洋大学, 海洋科学技術研究科, 教授 (50291026)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 刺胞動物 / 毒素 / 刺糸 / 毒性 / 構造決定 / クラゲ / 化学構造 / 刺傷被害 / ペプチド毒素 / ハブクラゲ / 麻痺活性 / 単離 / 刺胞 / タンパク質毒素 / エチゼンクラゲ |
Outline of Final Research Achievements |
A peptide toxin was isolated from the nematocysts of Chironex yamaguchii ( Japanese Name; Habu-kurage). The toxin showed lethality to the shrimp Palaemon paucidens. We compared lengths of the discharged nematocyst tubules of harmful and harmless jellyfish species. The results showed that the needle of harmful jellyfish was long enough to penetrate human epidermis and to mechanically stimulate pain receptor neuron and inject venom into corium tissue. On the other hand, less or none pain causing harmless jellyfish species has shorter needle which is not long enough to penetrate the epidermis. We concluded that difference in the length of the needle makes difference of degree of the pain in the jellyfish sting. The new compounds, cnidarins, were isolated from the Cnidarians and elucidated their structures.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] LC-MS/MS analysis of palytoxin analogues in blue humphead parrotfish Scarus ovifrons causing human poisoning in Japan.2013
Author(s)
Toshiyuki Suzuki, Ryuichi Watanabe, Ryoji Matsushima, Kenji Ishihara, Hajime Uchida, Saori Kikutsugi, Tomoko Harada , Hiroshi Nagai, Masao Adachi, Takeshi Yasumoto, Masakazu Murata
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Journal Title
Food Additives & Contaminants
Volume: 30
Issue: 8
Pages: 1358-1364
DOI
Related Report
Peer Reviewed
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[Presentation] 12-Epi-lyngbyatoxin A, a New Toxic Substance from the Cyanobacteria Moorea producens.2014
Author(s)
W. Jiang, W. Zhou, H. Uchida, M. Kikumori, K. Irie, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamio, H. Nagai
Organizer
The 10th IST Asia Pacific Conference on Animal, Plant and Microbial Toxins
Place of Presentation
中国・長沙
Year and Date
2014-06-14 – 2014-06-18
Related Report
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[Presentation] 12-Epi-lyngbyatoxin A, a New Toxic Substance from the Cyanobacteria Moorea producens2014
Author(s)
Weina Jiang, Wei Zhou, Hajime Uchida, Masayuki Kikumori, Kazuhiro Irie, Ryuichi Watanabe , Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai.
Organizer
10th IST Asia Pacific Conference on Animal, Plant and Microbial Toxins
Place of Presentation
中国 長沙市
Related Report
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