| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
For reactions using 2-benzyloxycarbonylcyclopentanone as the donor and cis-4-oxo-2-pentenal as the acceptor, the Michael addition reaction had been found to occur in the presence of base. However, in the absence of base, furans bearing a quaternary carbon substituent in the 2-position were found to form under the mild temperature condition of room temperature. The furan forming reaction was found to be accelerated in the presence of weak acids such as hexafluoroisopropyl alcohol and benzoic acid. Asymmetric reactions using the 8-phenylmenthyl group as a chiral auxiliary was found to proceed with diastereoselectivity up to 96% de.
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