| Project/Area Number |
24550127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
DOI Hisashi 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (00421818)
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| Co-Investigator(Renkei-kenkyūsha) |
KURAI Sachi 理化学研究所ライフサイエンス技術基盤研究センター, 標識化学研究チーム, リサーチアソシエイト
GOTO Miki 理化学研究所ライフサイエンス技術基盤研究センター, 標識化学研究チーム, リサーチアソシエイト (60565779)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | PET化学 / [11C]カルボキシル化 / [11C]二酸化炭素 / 常圧化学反応 / 高速化学反応 / 有機金属化学 / マイクロスケール反応器 / PET分子イメージング / PET標識化学 / 遠隔操作合成装置 |
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| Outline of Final Research Achievements |
Transition-metal-mediated rapid [11C]carboxylation using organoborane and [11C]carbon dioxide ([11C]CO2) produced in a cyclotron were explored, for developing an efficient route for the 11C-labeling of carboxyl groups. After extensive experiments, we found that the use of acetone was more effective for [11C]CO2-trapping at temperatures of ca. －98 °C. As a result, [11C]carboxylation was promoted at atmospheric pressure with a short reaction time of 3-5 min using a Rh(I) catalyst. The desired [11C]benzoic acid was obtained in the decay-corrected radiochemical yield of 38%-57%.
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