Understanding the molecular functions of the condensin complex in chromosome condensation
Project/Area Number |
24570006
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Genetics/Genome dynamics
|
Research Institution | The University of Tokyo |
Principal Investigator |
SUTANI Takashi 東京大学, 分子細胞生物学研究所, 助教 (30401524)
|
Research Collaborator |
SAKATA Toyonori
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 染色体 / 染色体凝縮 / 染色体分配 / 転写 / 分裂酵母 / ChIP-seq法 / 染色体高次構造 / ChIP-seq / 単鎖DNA / 細胞周期 |
Outline of Final Research Achievements |
The condensin plays an important role in shaping genomic DNA into compact, rod-like “condensed” chromosomes, and is required for faithful inheritance of genetic material. In this study, I aimed to reveal the molecular function of condensin in condensation through high resolution mapping of condensin binding locations in condensed chromosomes. I found that condensin targets and rewinds unwound DNA structure created by transcription during mitosis, thereby contributing to chromosome condensation.
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Report
(4 results)
Research Products
(10 results)