Studies on genes that contribute to stem cell differentiation and homeostasis

• Project/Area Number: 24570047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plant molecular biology/Plant physiology
• Research Institution: Kyoto University
• Principal Investigator: Tsugeki Ryuji 京都大学, 理学(系)研究科(研究院), 助教 (50303805)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 植物幹細胞

Outline of Final Research Achievements

In plants, the meristems harboring stem cells are central to post-embryonic formation of organs and tissues. To understand plant growth and development, it is important to reveal the mechanisms that contribute to stem cell differentiation and homeostasis. Arabidopsis thaliana VAH, EVAH and CUV were identified as genes that influence stem cell differentiation and homeostasis. Present data suggest that VAH and EVAH mediate negative control of stemness in the shoot and root. CUV facilitates auxin-mediated development including root meristem maintenance and apical-basal patterning of embryonic and gynoecium development. CUV differentially facilitates expression of genes, thereby influencing auxin-mediated development.

Research Products

• [Int'l Joint Research] フライブルグ大学(ドイツ)
• [Journal Article] The Arabidopsis ortholog of the DEAH-box ATPase Prp16 influences auxin-mediated development. (2015)
  • Author(s): Tsugeki, R., Terada, S.
  • Journal Title: Plant Signaling & Behavior Volume: 10 Issue: 10 Pages: e1074369-e1074369
  • DOI: 10.1080/15592324.2015.1074369
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CLUMSY VEIN, the Arabidopsis DEAH-box Prp16 ortholog, is required for auxin-mediated development. (2015)
  • Author(s): Tsugeki, R., Tanaka-Sato, N., Maruyama, N., Terada, S., Kojima, M., Sakakibara, H., Okada, K.
  • Journal Title: The Plant Journal Volume: 81 Issue: 2 Pages: 183-197
  • DOI: 10.1111/tpj.12721
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pattern dynamics in adaxial-abaxial specific gene expression are modulated by a plastid retrograde signal during Arabidopsis thaliana leaf development. (2013)
  • Author(s): Tameshige T, Fujita H, Watanabe K, Toyokura K, Kondo M, Tatematsu K, Matsumoto N, Tsugeki R, Kawaguchi M, Nishimura M, Okada K.
  • Journal Title: PLoS Genetics Volume: 97 Issue: 7 Pages: e1003655-e1003655
  • DOI: 10.1371/journal.pgen.1003655
  • Peer Reviewed
• [Presentation] 幹細胞らしさを負に制御する遺伝子の解析 (2016)
  • Author(s): 槻木 竜二、寺田 志穂
  • Organizer: 第57回 日本植物生理学会年会
  • Place of Presentation: 岩手大学（岩手県盛岡市）
  • Year and Date: 2016-03-18
• [Presentation] CLUMSY VEINは、オーキシンに依存した器官形成に関わる遺伝子の発現を促している (2013)
  • Author(s): 槻木竜二、佐藤（田中）奈々、丸山望、寺田志穂、小嶋美紀子、榊原均、岡田清孝
  • Organizer: 第54回 日本植物生理学会年会
  • Place of Presentation: 岡山大学
• [Remarks] 京都大学理学研究科植物学教室・年報（2015 年度）植物分子遺伝学分科
  • URL: http://www.bot.kyoto-u.ac.jp/annual/5_iden.html
• [Remarks] 京都大学理学研究科植物学教室・年報（2014年度）
  • URL: http://www.bot.kyoto-u.ac.jp/annual/5_iden.html
• [Remarks] 京都大学理学研究科植物学教室・年報（2013 年度）
  • URL: http://www.bot.kyoto-u.ac.jp/annual/5_iden.html
• [Remarks] 京都大学理学研究科植物学教室・年報（2012 年度） 植物分子遺伝学
  • URL: http://www.bot.kyoto-u.ac.jp/annual/5_iden.html