| Project/Area Number |
24570091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI SUGURU 徳島文理大学, 香川薬学部, 助教 (50325867)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セロトニントランスポーター / 遺伝子多型 / 動物行動 / 3'UTR / 学習 / 行動変化 / トランスクリプトーム / 3’UTR / 一細胞イメージング |
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| Outline of Final Research Achievements |
The serotonin transporter removes the neurotransmitter serotonin from the synaptic clefts and regulates the extracellular serotonin level. In the mollusc Lymnaea stagnalis, a large serotonergic neuron has been proposed as the key neuron in the neuromodulatory circuit for conditioned taste aversion learning (CTA), based on the behavioral experiments. In this study, we focused on variable number of tandem repeat (VNTR) in the 3’-untranslated region (3’-UTR) of Lymnaea serotonin transporter and the genome polymorphism, and the effects on animal behavior. We found two types of the VNTR (16 or 24 repeats) as the genome polymorphism, and each animal expressed either of one in the brain. We also obtained results indicating the effects of the VNTR on the animal behaviors, and the RNA-protein interaction specific for the VNTR.
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