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Association between the serotonin transporter polymorphism and learning behavior

Research Project

Project/Area Number 24570091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionTokushima Bunri University

Principal Investigator

SADAMOTO HISAYO  徳島文理大学, 薬学部, 講師 (70374220)

Co-Investigator(Renkei-kenkyūsha) KOBAYASHI SUGURU  徳島文理大学, 香川薬学部, 助教 (50325867)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsセロトニントランスポーター / 遺伝子多型 / 動物行動 / 3'UTR / 学習 / 行動変化 / トランスクリプトーム / 3’UTR / 一細胞イメージング
Outline of Final Research Achievements

The serotonin transporter removes the neurotransmitter serotonin from the synaptic clefts and regulates the extracellular serotonin level. In the mollusc Lymnaea stagnalis, a large serotonergic neuron has been proposed as the key neuron in the neuromodulatory circuit for conditioned taste aversion learning (CTA), based on the behavioral experiments. In this study, we focused on variable number of tandem repeat (VNTR) in the 3’-untranslated region (3’-UTR) of Lymnaea serotonin transporter and the genome polymorphism, and the effects on animal behavior. We found two types of the VNTR (16 or 24 repeats) as the genome polymorphism, and each animal expressed either of one in the brain. We also obtained results indicating the effects of the VNTR on the animal behaviors, and the RNA-protein interaction specific for the VNTR.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (4 results)

  • [Journal Article] Molecular basis of the dopaminergic system in the cricket Gryllus bimaculatus2013

    • Author(s)
      Watanabe T., Sadamoto H. and Aonuma H.
    • Journal Title

      Invert. Neurosci.

      Volume: 13 Issue: 2 Pages: 107-123

    • DOI

      10.1007/s10158-013-0153-1

    • NAID

      120005228686

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis.2013

    • Author(s)
      MurakamiJ,OkadaR,SadamotoH,KobayashiS,MitaK,SakamotoY,YamagishiM,HatakeyamaD,OtsukaE,OkutaA,SunadaH,TakigamiS,SakakibaraM,FujitoY,AwajiM,MoriyamaS,LukowiakK,ItoE
    • Journal Title

      Journal of Neuroscience

      Volume: 33(1) Pages: 371-83

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluorescence Cross-correlation Spectroscopy (FCCS) to Observe Dimerization of Transcription Factors in Living Cells.2013

    • Author(s)
      Sadamoto H, Muto H.
    • Journal Title

      Methods in Molecular Biology

      Volume: 977 Pages: 229-41

    • Related Report
      2012 Research-status Report
  • [Journal Article] Excitatory effects of GABA on procerebrum neurons in a slug.2012

    • Author(s)
      Kobayashi S, Matsuo R, Sadamoto H, Watanabe S, Ito E
    • Journal Title

      Journal of Neurophysiology

      Volume: 108(4) Pages: 989-98

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] De novo sequencing and transcriptome analysis of the central nervous system of mollusc Lymnaea stagnalis by deep RNA sequencing.2012

    • Author(s)
      Sadamoto H, Takahashi H, Okada T, Kenmoku H, Toyota M, Asakawa Y.
    • Journal Title

      PLoS One

      Volume: 7(8)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] De novo sequencing and transcriptome analysis of non-model animal by deep RNA sequencing2015

    • Author(s)
      Hisayo Sadamoto
    • Organizer
      Inaugural Symposium of the Phytochemical Society of Asia (ISPSA) 2015
    • Place of Presentation
      徳島文理大学徳島キャンパス
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 興奮性シナプス後部足場蛋白質GKAP/SAPAPアイソフォームのシナプス形成期における局在解析2015

    • Author(s)
      定本久世
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸国際展示場1号館
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synaptic localization and function of VAMP4 in developing inhibitory neurons2014

    • Author(s)
      Hisayo Sadamoto, Toshihiko Kuriu, Yuchio Yanagawa, Shiro Konishi
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] The brain responses to hunger and satiation in mollusc Lymnaea stagnalis2012

    • Author(s)
      Hisayo Sadamoto, Mai Ohmichi, Noriyuki Hama, Suguru Kobayashi
    • Organizer
      日本比較生理生化学会
    • Place of Presentation
      総合研究大学院大学葉山キャンパス
    • Related Report
      2012 Research-status Report
  • [Book] 研究者が教える動物実験 第1巻 感覚2015

    • Author(s)
      尾崎まみこ・村田芳博・藍浩之・定本久世・吉村和也・神崎亮平・日本比較生理生化学会 編集
    • Total Pages
      199
    • Publisher
      共立出版
    • Related Report
      2015 Annual Research Report
  • [Book] 研究者が教える動物実験 第2巻 神経・筋2015

    • Author(s)
      尾崎まみこ・村田芳博・藍浩之・定本久世・吉村和也・神崎亮平・日本比較生理生化学会 編集
    • Total Pages
      221
    • Publisher
      共立出版
    • Related Report
      2015 Annual Research Report
  • [Book] 研究者が教える動物実験 第3巻 行動2015

    • Author(s)
      尾崎まみこ・村田芳博・藍浩之・定本久世・吉村和也・神崎亮平・日本比較生理生化学会 編集
    • Total Pages
      222
    • Publisher
      共立出版
    • Related Report
      2015 Annual Research Report
  • [Book] 研究者が教える動物飼育 【1】巻2012

    • Author(s)
      針山孝彦・小柳光正・嬉 正勝・妹尾圭司・小泉 修・日本比較生理生化学会 編集
    • Total Pages
      226
    • Publisher
      共立出版
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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