Structural analysis of pore-forming CEL-III complex.
| Project/Area Number |
24570135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
UNNO Hideaki 長崎大学, 工学研究科, 助教 (10452872)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | X線結晶構造解析 / 膜孔形成毒素 / CEL-III / 膜孔形成複合体 / Cucumaria. echinata / 溶血性レクチン / レクチン / PFT |
|---|
| Outline of Final Research Achievements |
CEL-III is a hemolytic lectin from C. echinata and performs as a pore-forming toxin. Structural analysis of pore-forming CEL-III complex was carried out to elucidate its pore-formation mechanism. A crystal structure of the CEL-III complex was determined at 2.9 angstrom resolution. A detail of pore-forming mechanism of the CEL-III was clarified by the structural analysis.
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Report
(4 results)
Research Products
(25 results)
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[Presentation] Structural analysis of Pore-Forming CEL-III2014
Author(s)
Hideaki Unno, Shuichiro Goda, and Tomomitsu Hatakeyama
Organizer
Twenty-Third Congress and General Assembly of the International Union of Crystallography
Place of Presentation
Montreal, Canada
Year and Date
2014-08-05 – 2014-08-12
Related Report
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