Analyses of nucleotide excision repair factors in the regulation of gene expression
| Project/Area Number |
24570156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
NARITA Takashi 大阪大学, 生命機能研究科, 特任助教 (50437399)
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| Research Collaborator |
SAIJO Masafumi 大阪大学, 大学院生命機能研究科, 准教授 (90221986)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | DNA修復 / 転写 / 遺伝情報発現 / 色素性乾皮症 / 遺伝子発現制御 / 転写伸長 / ヌクレオチド除去修復 / 遺伝子発現 |
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| Outline of Final Research Achievements |
The results showed that XPG-TFIIH complex interacts with transcription elongation complex. Transcription assays and chromatin immunoprecipitation experiments revealed that XPG-TFIIH complex is involved in regulating a wide range of gene expression. Furthermore, the functions of XPG-TFIIH complex in transcription have relevance to the CS features in XP-G/CS patients. These results will be helpful to understand the relationship between the mutations in XP-G patients and their clinical features at a molecular level.
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Report
(4 results)
Research Products
(2 results)
