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2014 Fiscal Year Final Research Report

Analyses of nucleotide excision repair factors in the regulation of gene expression

Research Project

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Project/Area Number 24570156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional biochemistry
Research InstitutionOsaka University

Principal Investigator

NARITA Takashi  大阪大学, 生命機能研究科, 特任助教 (50437399)

Research Collaborator SAIJO Masafumi  大阪大学, 大学院生命機能研究科, 准教授 (90221986)
Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsDNA修復 / 転写 / 遺伝情報発現 / 色素性乾皮症
Outline of Final Research Achievements

The results showed that XPG-TFIIH complex interacts with transcription elongation complex. Transcription assays and chromatin immunoprecipitation experiments revealed that XPG-TFIIH complex is involved in regulating a wide range of gene expression. Furthermore, the functions of XPG-TFIIH complex in transcription have relevance to the CS features in XP-G/CS patients. These results will be helpful to understand the relationship between the mutations in XP-G patients and their clinical features at a molecular level.

Free Research Field

分子生物学

URL: 

Published: 2016-06-03  

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