| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
It was found that human SH3YL1, which contains a novel phosphoinositide-binding domain named the SYLF domain, is involved in endocytosis of epidermal growth factor receptor. In vitro, SH3YL1 not only bound to liposomes, but also mediated interactions between liposomes that it resides, promoting aggregation of membrane vesicles. This study also succeeded in obtaining a knowledge about the positively-charged residues in the SYLF domain that participate in lipid-binding, therefore will provide a novel molecular basis of endocytosis.
|
