Physiological analysis of polyunsaturated fatty acid (PUFA) in Saccharomyces cerevisiae and its application to improving stress tolerance
| Project/Area Number |
24580109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
TANAKA Koichi 京都大学, (連合)農学研究科(研究院), 研究員 (90282615)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMA Jun 龍谷大学, 農学部, 教授 (00343822)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 出芽酵母 / 不飽和脂肪酸 / ストレス耐性 / バイオエタノール / 酢酸 / 微生物 / 脂肪酸 / ステロール / 芳香族アミノ酸 |
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| Outline of Final Research Achievements |
Lignocellulose hydrolysates contain aliphatic acids, such as acetic acid, that negatively affects the fermentation ability of S. cerevisiae. In this study, we found that the strain overexpressing HAA1 gene acquired a higher level of acetic acid tolerance. The ethanol production ability of HAA1-overexpressing strain was not influenced by acetic acid addition. We believe that this technology has the great potential to reduce bioethanol production costs.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Identification of an acetate-tolerant strain of Saccharomyces cerevisiae and characterization by gene expression analysis2012
Author(s)
Haitani, Y., Tanaka, K., Yamamoto, M., Nakamura, T., Ando, A., Ogawa, J. and Shima, J.
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Journal Title
Journal of Bioscience and Bioengineering
Volume: 114(6)
Issue: 6
Pages: 648-651
DOI
NAID
Related Report
Peer Reviewed
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