Study on the role of protein acetylation in translational regulation in bacteria
| Project/Area Number |
24580133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOSONO Saori 東京大学, 生物生産工学研究センター, 特任准教授 (90321760)
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| Co-Investigator(Renkei-kenkyūsha) |
DOHMAE Naoshi 理化学研究所, 環境資源科学研究センター, ユニットリーダー (00321787)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | タンパク質アセチル化 / タンパク質スクシニル化 / 翻訳制御 / EFTu / 枯草菌 / SILAC / リジンアセチル化 / スクシニル化 / 翻訳後修飾 / バクテリア / 翻訳伸長因子 |
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| Outline of Final Research Achievements |
The role of protein acylation in translation elongation factor (EF) Tu in Bacillus subtilis was investigated. Acetylation and succinylation of Bs-EFTu was dynamically changed in response to carbon sources and growth phases. We revealed succinylation in the domain-3 negatively regulates the function of EFTu and the growth.
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Report
(4 results)
Research Products
(23 results)
