| Project/Area Number |
24580182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kobe University |
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Principal Investigator |
HASHIMOTO TAKASHI 神戸大学, (連合)農学研究科(研究院), 准教授 (90362764)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUNO Masashi 神戸大学, 大学院農学研究科, 教授
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| Research Collaborator |
IWAMI Shiho
SHIMOAKI Tomohiro
OKAMOTO Mayumi
KANAZAWA Kazuki
AIHARA Yoshiko
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 薬物代謝第Ⅱ相酵素 / ケンフェロール配糖体 / 西洋ワサビ葉 / ICRマウス / IQI/Jic(ICR)無菌マウス / 4-ヒドロキシフェニル酢酸 / ルチン / 3,4-ジヒドロキシフェニル酢酸 / 薬物代謝第II相酵素 |
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| Outline of Final Research Achievements |
The study with ICR mice and IQI/Jic(ICR) germ-free mice demonstrated that the intestinal flora was involved in the activated drug-metabolizing phase II enzymes by the consumption of 3-O-[2-O-(β-D-xylopyranosyl)-β-D-galactopyranosyl]-kaempferol derived from horseradish leaves. 4-Hydroxyphenylacetic acid, which is a catabolite from the kaempferol glycoside, played an important role in the activation of drug-metabolizing phase II enzymes.
The consumption of rutin, one of quercetin glycosides, also activated drug-metabolizing phase II enzymes in mice, and the active compound was 3,4-dihydroxyphenylacetic acid, which is a catabolite of rutin.
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