The role of proton-sensing G protein-coupled receptors on blood vessel formation and function
Project/Area Number |
24580436
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Basic veterinary science/Basic zootechnical science
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Research Institution | Meiji University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | GPCR / OGR1 / GPR4 / ゼブラフィッシュ / Gタンパク質共役型受容体 / プロトン / 生理活性 / シグナル伝達 / G蛋白共役型受容体 / G蛋白共役型受容体 |
Outline of Final Research Achievements |
OGR1, GPR4, TDGA8 and G2A are the unique GPCRs which sense extracellular proton (OGR1 family). I assume that this family participates in blood vessel formation and function under acidic condition. Zebrafish offers a useful system to analyze blood vessel formation and function. The homologous OGR1 family genes which exist in the zebrafish genome were analyzed by this research as the first step to prove the above hypothesis. The result shows that the homologous genes encode the GPCRs which sense extracellular proton like the human OGR1 family does.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Extracellular acidification activates ovarian cancer G-protein-coupled receptor 1 and GPR4 homologs of zebra fish2015
Author(s)
Mochimaru Y, Azuma M, Oshima N, Ichijo Y, Satou K, Matsuda K, Asaoka Y, Nishina H, Nakakura T, Mogi C, Sato K, Okajima F and Tomura H.
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Journal Title
Biochem Biophys Res Commun
Volume: 457
Pages: 493-9
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model2013
Author(s)
Aoki H, Mogi C, Hisada T, Nakakura T, Kamide Y, Ichimonji I, Tomura H, Tobo M, Sato K, Tsurumaki H, Dobashi K, Mori T, Harada A, Yamada M, Mori M, Ishizuka T and Okajima F.
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Journal Title
Related Report
Peer Reviewed
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