Synthesis of planar chiral polyaromatic compounds and application to the asymmetric catalysis
| Project/Area Number |
24590006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 有機化学 / パラシクロファン / 有機分子触媒 / 不斉配位子 / 面不斉 / [2.2]パラシクロファン / ビスオキサゾリン配位子 / チオウレア触媒 / 合成化学 / ホスフィン触媒 / 酸－塩基複合型不斉触媒 |
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| Outline of Final Research Achievements |
The [2.2]paracyclophane (PCP)-based planar-chiral organocatalysts and ligands, 1) which had functional group(s) through the spacer aryl group or 2) which were designed for regio- or stereoselectivity control based on the π－π, CH－π, or cation－π interaction, were synthesized and evaluated. Among PCP organocatalysts and ligands tested, the catalyst whose phosphine unit is connected with a cyclopanol via a spacer benzene ring and C2-symmetric bis(oxazoline) ligands having the spacer with a sterically demanding substituent were found to catalyze organic transformations with high enantiocontrol.
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Report
(4 results)
Research Products
(11 results)
