Lithium Amide in Consecutive Aminolithiation-Carbolithiation
| Project/Area Number |
24590035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 有機化学 / 薬学 / カルバニオン / 合成化学 / 活性種 |
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| Outline of Final Research Achievements |
An addition reaction of nitrogen nucleophiles to C=C double bonds is important for C-N bond formation. Addition of lithium amides to olefins affords alkyllithiums, which is powerful nucleophiles and useful for additional bond forming reactions. We developed consecutive aminolithiation-carbolithiation reactions, and asymmetric one-pot [N+2+n] cyclization reactions. Asymmetric total synthesis of some natural products was also achieved by using our developed reactions.
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Report
(5 results)
Research Products
(32 results)
