Structure of supersaturated solution of poorly water-soluble drug indexed by mobility and diffusibility and the correlation with membrane permeability
| Project/Area Number |
24590045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
MORIBE Kunikazu 千葉大学, 薬学研究科(研究院), 教授 (50266350)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Keiji 千葉大学, 大学院薬学研究院, 名誉教授 (50110341)
HIGASHI Kenjirou 千葉大学, 大学院薬学研究院, 助教 (40451760)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 固体分散体 / 過飽和 / 固体分散体過飽和 |
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| Outline of Final Research Achievements |
The decrease of the substituent ratio of succinoyl group in HPMC-AS promoted the inhibition effect of drug crystallization. NMR measurements revealed that HPMC-AS suppressed the molecular mobility of drug and formed the hydrophobic interaction with drug. The molecular interaction between drug and HPMC-AS was strongest in acetyl group and weakest in succinoyl group of HPMC-AS, indicated by saturation transfer difference (STD)-NMR measurements. The molecular interaction between drug and HPMC-AS revealed by NMR measurement showed good correlation with the inhibitory effect of drug crystallization.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution2014
Author(s)
Ueda, K., Higashi, K., Kataoka, M., Yamashita, S., Yamamoto, K., Moribe, K.
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Journal Title
Eur. J. Pharm. Sci.
Volume: 62
Pages: 293-300
DOI
Related Report
Peer Reviewed
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