Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Outline of Final Research Achievements |
Voltage-dependent K+ channels (Kv) regulates active potential by selectively permeating K+ through cell membrane, playing critical roles in neurotransmission and muscle contraction. To date, voltage-dependent confomational changes of Kv remais elusive, due to lack of the method to analyze the strucutre under membrane potential. The aim of this study is to reveal structrural mechanism of Kv that senses membrane potential. We established a novel method to analyze structure under membrane potential. Based on the results obtained here, we propose that Kv undergoes structural equilibrium that shifts depending upon the membrane potential.
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