| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We tried to manufacture the sheet formulation containing anticancer drug 5-FU for application to liver surface. In addition, we examined the influence of metabolic inhibitors on the hepatic disposition of 5-FU, aiming to optimize the sheet formulation. We could manufacture the sheet formulation containing anticancer drug 5-FU for application to liver surface by employing biodegradable macromolecules poly (lactic-co-glycolic acid) and hydroxypropyl cellulose. From the sheet formulation, the containing 5-FU was gradually released for a long period time. Moreover, we found that gimeracil a metabolic inhibitor was useful to improve the bioavailability of 5-FU in the liver, and obtained the optimal combination ratio.
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