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The development study of highly sensitive chemiluminescent probe for tumor hypoxia in vivo imaging

Research Project

Project/Area Number 24590054
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionGifu Pharmaceutical University

Principal Investigator

OKUDA Kensuke  岐阜薬科大学, 薬学部, 准教授 (00311796)

Co-Investigator(Kenkyū-buntansha) NAGASAWA Hideko  岐阜薬科大学, 薬学部, 教授 (90207994)
Co-Investigator(Renkei-kenkyūsha) KONDO Shinae  東京工業大学, 生命理工学研究科, 教授 (40314182)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords化学発光 / 分析科学 / 低酸素 / イメージング / 高感度 / 低侵襲性 / 非侵襲性 / がん / インビボ / 癌
Outline of Final Research Achievements

Chemiluminescence imaging has the advantage of lower detection limits and improved signal-to-noise ratio compared to existing fluorescent imaging. To visualize the hypoxic status of various tumor cells which are considered to be closely related to malignancy, I developed a probe that emit chemiluminescence, which is suitable for non-invasive bioimaging, under hypoxia. To utilize hypoxia selective reductive metabolic reaction, I designed and synthesized chemiluminescent probe molecules rationally. Then, I evaluated them using nitroreductase to select the molecule to emit luminescence from the reaction. Next, I analyzed reaction products to show the molecule worked as the enzyme substrate to emit luminescence. As a result, I obtained significant expertise to apply the molecule for in vivo chemiluminescent imaging.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 Other

All Presentation (11 results) (of which Invited: 1 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 低酸素イメージングを目指す化学発光プローブの開発研究2014

    • Author(s)
      奥田健介、坂享、平山祐、永澤秀子
    • Organizer
      第2回低酸素研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] s/nの向上を目指した低酸素応答性近赤外蛍光プローブの開発に関する検討2014

    • Author(s)
      西野正人、奥田健介、河野樹、平山祐、永澤秀子
    • Organizer
      第60回日本薬学会東海支部大会
    • Place of Presentation
      鈴鹿
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] The development study of hypoxia responsive chemiluminescent probe for tumor hypoxia imaging2014

    • Author(s)
      Kensuke Okuda, Toru Ban, Tasuku Hirayama, and Hideko Nagasawa
    • Organizer
      AACR Annual Meeting 2014
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腫瘍低酸素イメージングを目指した低酸素応答性化学発光プローブの開発研究2014

    • Author(s)
      奥田健介、坂享、平山祐、永澤秀子
    • Organizer
      日本薬学会年会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 腫瘍低酸素イメージングを目指した 低酸素応答性化学発光プローブの開発研究2013

    • Author(s)
      坂 享、奥田健介、平山祐、永澤秀子
    • Organizer
      第43回複素環化学討論会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Research-status Report
  • [Presentation] 腫瘍低酸素イメージングを目指した低酸応答性化学発光プローブの開発研究2013

    • Author(s)
      奥田健介、坂享、平山祐、永澤秀子
    • Organizer
      第31回メディシナルケミストリーシンポジウム
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] 近赤外蛍光プローブからみた癌増感のターゲット - 低酸素 -2013

    • Author(s)
      奥田健介
    • Organizer
      第15回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] がんのin vivo イメージングを目指す低酸素応答性近赤外蛍光プローブ の論理的分子設計と合成2012

    • Author(s)
      奥田健介
    • Organizer
      第7回日本分子イメージング学会学術集会
    • Place of Presentation
      浜松
    • Related Report
      2012 Research-status Report
  • [Presentation] 低酸素がんのin vivoイメージングを目指す 低酸素応答性近赤外蛍光プローブの開発2012

    • Author(s)
      河野樹
    • Organizer
      日本ケミカルバイオロジー研究会第7回年会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of a novel hypoxia-activatable near-infrared fluorescent probe for tumor hypoxia imaging2012

    • Author(s)
      Kensuke Okuda
    • Organizer
      the 2012 World Molecular Imaging Congress
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2012 Research-status Report
  • [Presentation] 低酸素がんのin vivoイメージングを目指す低酸素応答性近赤外蛍光プローブの開発2012

    • Author(s)
      奥田健介
    • Organizer
      第10回がんとハイポキシア
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Remarks] 岐阜薬科大学 創薬化学大講座 薬化学研究室 ホームページ

    • URL

      http://www.gifu-pu.ac.jp/lab/yakka/Home.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 岐阜薬科大学 創薬化学大講座 薬化学研究室

    • URL

      http://www.gifu-pu.ac.jp/lab/yakka/Home.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 岐阜薬科大学 創薬化学大講座 薬化学研究室

    • URL

      http://www.gifu-pu.ac.jp/lab/yakka/Home.html

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 低酸素関連眼疾患のインビボ用診断薬及び治療用組成物2014

    • Inventor(s)
      福田慎一、大鹿哲郎、永澤秀子、奥田健介
    • Industrial Property Rights Holder
      福田慎一、大鹿哲郎、永澤秀子、奥田健介
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-09-30
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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