Nano vectors with biosurfactant MEL-A
| Project/Area Number |
24590060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hiromitsu 愛知学院大学, 薬学部, 教授 (30275094)
INHO Yoshikazu 愛知学院大学, 薬学部, 講師 (90434547)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | nano vectors / liposome / biosurfactant / gene transfection / medical treatment / membrane fusion / ナノ遺伝子ベクター / バイオ・ナノ遺伝子 / 正電荷リポソイーム / バイオサーファクタント / 遺伝子導入 / レーザ顕微鏡 / 金ナノ粒子 / RNA干渉 / 正電荷リポソーム / ＲＮＡ干渉 |
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| Outline of Final Research Achievements |
The liposomes made by biosurfactant(MEL-A) dramatically increased the efficiency in transfection of plasmid DNAs and foreign DNAs. The efficiency by nano vector is derived from the unique pathway similar to that by certain RNA virus vectors. From the safety and low toxicity the nano vector would appear to be a new operating technique with great potential in gene transfection and drug delivery in medical treatment.
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Report
(5 results)
Research Products
(31 results)
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[Journal Article] Phosphorylation of syntaxin-3 at Thr 14 negatively regulates exocytosis in RBL-2H3 cells2016
Author(s)
Tadokoro, S., Sibata, T., Inoh, Y., Amano, T., Nakanishi, M., Hirashima, N.
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Journal Title
Cell Biol. Int.,
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Inhibitory effects of a cationic liposome on allergic reaction.2013
Author(s)
Inoh, Y., Tadokoro, S., Tanabe, H., Inoue,M., Nakanishi., M., Furuno. T.
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Journal Title
Biochem. Pharmacol.
Volume: 86
Pages: 1731-1738
Related Report
Peer Reviewed
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