| Project/Area Number |
24590065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKANISHI Toyofumi 大阪医科大学, 医学部, 准教授 (10247843)
SATO Takako 大阪医科大学, 医学部, 講師 (10530420)
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| Research Collaborator |
MIKI Akihiro 大阪医科大学, 法医学, 特別協力研究員
KAMATA Tooru 大阪医科大学, 法医学, 特別協力研究員
SHIMA Noriaki 大阪医科大学, 法医学, 特別協力研究員
ZAITSU Kei 大阪医科大学, 法医学, 特別協力研究員
KATAGI Munehiro 大阪府警察本部, 科学捜査研究所, 主席研究員
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 毛髪 / 乱用薬物 / 質量分析 / イメージング / 毛髪分析 / TOF/TOF |
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| Outline of Final Research Achievements |
A novel mass spectrometry imaging procedure was established for the visualization of drugs incorporated into hair. Mass spectrometry imaging was performed on the longitudinal sections of single scalp hair shafts from volunteers who took an OTC medicine containing methoxyphenamine, a model drug of methamphetamine. Drug positive bands were observed on the hair specimens in accordance with their schedule of administration. To investigate the mechanism of drug incorporation into hair, single hair specimens were collected by plucking out with the roots intact, and analyzed by the established method.
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