| Project/Area Number |
24590110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Juntendo University (2015)
Gunma University (2012-2014) |
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Principal Investigator |
Kubohara Yuzuru 順天堂大学, スポーツ健康科学研究科, 教授 (00221937)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Itaru 群馬大学, 生体調節研究所, 教授 (60143492)
OSHIMA Yoshiteru 東北大学, 大学院薬学研究科, 教授 (00111302)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞性粘菌 / DIF / がん / 糖尿病 / ミトコンドリア / 走化性運動 / トリパノソーマ / 免疫 |
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| Outline of Final Research Achievements |
DIF-1, a low-molecular weight compound found in the cellular slime mold Dictyostelium discoideum, and its derivatives possess multiple biological activities, such as anti-proliferative and glucose-uptake-promoting activities in vitro in mammalian cells. We have investigated the pharmacological functions of DIFs and indicated that DIFs may be good lead compounds for the development of novel anti-tumor, anti-obesity/anti-diabetes, and anti-Trypanosoma drugs. In addition, we have found that DIFs may function, at least in part, by disturbing mitochondrial activity in mammalian cells.
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