Role of thermo-sensitive TRP channels in stress-induced visceral hyperesthesia: analyses of samples from disease model animals and patients
| Project/Area Number |
24590118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Josai International University |
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Principal Investigator |
HORIE SYUNJI 城西国際大学, 薬学部, 教授 (50209285)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | TRPチャネル / カプサイシン / 痛覚過敏 / 知覚過敏 / 微小炎症 / ストレス / 過敏性腸症候群 / 機能性ディスペプシア / 潰瘍性大腸炎 / 食後不定愁訴症候群 / 病態モデル / TRPV1 / TRPA1 / 求心性一次知覚神経 / 知覚過敏性 / TRPM2 / 免疫組織化学 / クローン病 / 遠位結腸 / 温度感受性TRPチャネル / 機能性胃腸症 / 炎症性腸疾患 / ヒト組織標本 |
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| Outline of Final Research Achievements |
Psychological stress induces impairment of gastrointestinal tracts, leading to functional gastrointestinal diseases (irritable bowel syndrome, functional dyspepsia) accompanied by abdominal pain. The present study was designed with those disease model animals in order to elucidate the causes of functional gastrointestinal diseases. As an important result, the stress induces the increased number of thermosensitive TRP channel-expressing nerve fibers, resulting in the hypersensitivity of visceral pain. Therefore, the inhibition of the abnormality of TRP channels-expressing nerves in gut will make a contribution to the treatment of functional gastrointestinal diseases.
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Report
(5 results)
Research Products
(46 results)
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[Journal Article] Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon2014
Author(s)
Sakai H, Sagara A, Matsumoto K, Jo A, Hirosaki A, Takase K, Sugiyama R, Sato K, Ikegami D, Horie S, Matoba M, Narita M.
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Journal Title
Pharmacol. Res.
Volume: 87
Pages: 71-79
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.2014
Author(s)
Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S.
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Journal Title
J Pharmacol Exp Ther.
Volume: 348
Issue: 3
Pages: 383-392
DOI
Related Report
Peer Reviewed / Open Access
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[Book] Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: from Bench to Bedside2014
Author(s)
Tashima, K., Kabashima, M., Matsumoto, K., Yano, S., Hagen S.J., Horie, S.
Total Pages
364
Publisher
InTech, Rejeka, Croatia
Related Report
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[Book] Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: from Bench to Bedside2014
Author(s)
Horie, S., Raimura, M., Matsumoto, K., Namiki, T., Terasawa, K., Priestley, J.V., Tashima, K
Total Pages
364
Publisher
InTech, Rejeka, Croatia
Related Report
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