| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Psychological stress induces impairment of gastrointestinal tracts, leading to functional gastrointestinal diseases (irritable bowel syndrome, functional dyspepsia) accompanied by abdominal pain. The present study was designed with those disease model animals in order to elucidate the causes of functional gastrointestinal diseases. As an important result, the stress induces the increased number of thermosensitive TRP channel-expressing nerve fibers, resulting in the hypersensitivity of visceral pain. Therefore, the inhibition of the abnormality of TRP channels-expressing nerves in gut will make a contribution to the treatment of functional gastrointestinal diseases.
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