| Project/Area Number |
24590182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
TAGUCHI MASATO 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20324056)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIDA Fukiko 富山大学, 大学院医学薬学研究部(医学) (30223100)
SAITO Kazuyoshi 富山大学, 大学院医学薬学研究部(医学) (30566097)
HIRONO Keiichi 富山大学, 大学院医学薬学研究部(医学) (80456384)
ISHIDA Kazuya 富山大学, 大学院医学薬学研究部(薬学) (90550509)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 小児 / フレカイニド / タダラフィル / 薬物動態評価法 / 循環器官用薬 / 個別投与設計 / 小児薬物動態 / シルデナフィル / 治療薬物モニタリング / 薬物代謝 |
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| Outline of Final Research Achievements |
There is a limited number of reports documenting the pharmacokinetics of cardiovascular drugs in children. One of the reasons is that frequent blood sampling in children is physically and ethically very difficult. On the other hand, we previously reported that the peak-and-trough sampling design is useful for the clinical repeated-dose pharmacokinetic trials. In this study, we evaluate the pharmacokinetic variability of flecainide and tadalafil in Japanese pediatric patients by the application of the recently developed method.
A large interindividual variability was observed in plasma concentrations of flecainide, and the estimated values of oral clearance (CL/F) correlated highly with those of apparent volume of distribution (V/F). The mean CL/F and V/F values of tadalafil were 0.149 L/hr/kg and 1.87 L/kg, respectively, which were higher than those reported in adults. These efforts could provide an important basis for the proper use of cardiovascular drugs in children.
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