| Project/Area Number |
24590193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
KUROSAKI Yuji 岡山大学, 医歯(薬)学総合研究科, 教授 (90161786)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASAKI Hiromu 松山大学, 薬学部, 教授 (60125151)
AIBA Tetsuya 岡山大学, 大学院医歯薬学総合研究科, 准教授 (00231754)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 局所薬物動態 / 局所利用率 / ドドラッグデリバリーシステム / マイクロダイアリシス / 微小透析 / ファーマコキネティクス / 拡散モデル / 筋肉内薬物拡散動態 / 局所冷却 / 遊離形薬物濃度 / 時間遅れ補正 / 吸着動態 / 筋肉内拡散動態 / 局所血流 / 微小透析（マイクロダイアリシス） / 薬物動態 |
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| Outline of Final Research Achievements |
To realize a well-controlled regionally confined drug action, a new scientific platform that covers topical bioavailability and topical pharmacokinetics has been required. In this study, lateral diffusion and systemic clearance processes of drugs applied to the abdominal muscle of the rat was monitored by microdialysis (MD) and a new concept, focal bioavailability, based on unbound drug concentration profiles in specific site is evaluated with its pharmacokinetic model.
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