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Research on the therapy for pancreatic cancer by PPARgamma agonists

Research Project

Project/Area Number 24590225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionMukogawa Women's University

Principal Investigator

OKAMURA Noboru  武庫川女子大学, 薬学部, 教授 (60379401)

Co-Investigator(Renkei-kenkyūsha) YAMAMORI Motohiro  武庫川女子大学, 薬学部, 講師 (10444613)
FUJITA Megumi  武庫川女子大学, 薬学部, 講師 (50509966)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords膵臓がん / PPARγ / アポトーシス
Outline of Final Research Achievements

Effect of troglitazone, a PPARγ agonist, on human pancreatic cancer cell lines, troglitazone exhibited inhibitory activity on cell proliferation in concentration dependent manner. Also, it was suggested that PPARγ did not involved in the activity. Although no important pathway was revealed in Panc-1 cells, the JNK pathway was involved in the activity in MIA Paca-2 cells. In addition, effect of oral administration of troglitazone on tumor progression in tumor-bearing mouse using MIA Paca-2 cells was investigated. Although any significant difference was not observed, tumor volume and weight tended to decrease, suggesting the possibility of troglitazone having anti-tumor effect in in vivo.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (1 results)

  • [Journal Article] TNF-α -857C>T genotype is predictive of clinical response after treatment with definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.2013

    • Author(s)
      H. Omatsu, A. Kuwahara, M. Yamamori, M. Fujita, T. Okuno, I. Miki, T. Tamura, K. Nishiguchi, N. Okamura, T. Nakamura, T. Azuma, T. Hirano, K. Ozawa, M. Hirai.
    • Journal Title

      Int J Med Sci.

      Volume: 10 Issue: 12 Pages: 1755-1760

    • DOI

      10.7150/ijms.6749

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] L-type voltage-dependent calcium channel is involved in the snake venom group IA secretory phospholipase A2-induced neuronal apoptosis.2013

    • Author(s)
      T. Yagami, Y. Yamamoto, H. Kohma, T. Nakamura, N. Takasu, N. Okamura.
    • Journal Title

      Neurotoxicology

      Volume: 35 Pages: 146-153

    • DOI

      10.1016/j.neuro.2012.12.009

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Potential tumor markers of renal cell carcinoma: α-enolase for postoperative follow-up and galectin-1 and galectin-3 for primary detection.2013

    • Author(s)
      N. Kaneko, A. Gotoh, N. Okamura, E. Matsuo, S. Terao, M. Watanabe, T. Nakamura, M. Ikekita, K. Okumura, O. Nishimura.
    • Journal Title

      Int J Urol.

      Volume: 20 Issue: 5 Pages: 530-535

    • DOI

      10.1111/j.1442-2042.2012.03206.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma.2012

    • Author(s)
      Fujita M, Tohji C, Honda Y, Yamamoto Y, Nakamura T, Yagami T, Yamamori M, Okamura N.
    • Journal Title

      Int J Med Sci

      Volume: 9 Issue: 7 Pages: 555-566

    • DOI

      10.7150/ijms.4455

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of the mevalonate pathway in the antiproliferative effect of zoledronate on ACHN renal cell carcinoma cell2011

    • Author(s)
      Fujita M, et al
    • Journal Title

      Oncol.Rep.

      Volume: 27 Pages: 1371-1376

    • DOI

      10.3892/or.2012.1683

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 15デオキシ-デルタ12 14-プロスタグランジンJ2の細胞膜上における標的分子であるHSP70の抗体は神経細胞死を誘導する2012

    • Author(s)
      山本 泰弘、高馬 宏美、藤田 恵、山森 元博、中村 任、岡村 昇、矢上 達郎
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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