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Expression of ion-channel proteins in the cutaneous mechanoreceptors of normal rats and atopic dermatitis model mice

Research Project

Project/Area Number 24590253
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionTottori University

Principal Investigator

KAIDOH Toshiyuki  鳥取大学, 医学部, 教授 (70268837)

Research Collaborator KAMEIE Toshio  鳥取大学, 技術部, 技術専門職員
MORINO Shinichi  鳥取大学, 技術部, 技術専門職員
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords皮膚 / 感覚 / 神経 / アトピー性皮膚炎 / チャネル分子 / 感覚受容器 / 接着分子 / 機械受容器
Outline of Final Research Achievements

Immunohistochemistry showed that ion-channel proteins, Piezo2, TRPV2, ASIC2, and ASIC3 were expressed in the palisade nerve endings(PN)of rat vellus hairs. These results means that the PN in this skin region might be function as not only mechanoreceptor but also thermoreceptor and nociceptor. Immunoelectron microscopy confirmed that ion-channel receptor proteins, Piezo2 and ASIC2 were expressed on the cytoplasmic surface of plasma membrane of the sensory nerve endings. These proteins probably function as receptors of mechanosensation of the lanceolate nerve endings in the rat auricular skin.
In the auricular skin of the normal NC-hairless mice the expression of ion-channel proteins was inconspicuous in the PN, whereas in that of the dinitrofluorobenzene-induced atopic dermatitis mice, TRPV4, TRPA1, ASIC2 and ASIC3 were detected in the PN. Induction and expression of these ion-channel proteins in PN might cause itchy skin sensation in this atopic dermatitis model.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013 2012

All Journal Article (1 results) (of which Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Expression of ion-channel proteins in the cutaneous mechanoreceptors of mice model of atopic dermatitis2015

    • Author(s)
      Toshiyuki Kaidoh, Toshio Kameie
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] アトピー性皮膚炎モデルマウスにおけるイオンチャネルタンパク質の発現2015

    • Author(s)
      海藤俊行
    • Organizer
      第120回日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場・展示場(神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 皮膚感覚受容器におけるイオンチャネルタンパク質の局在の検討2014

    • Author(s)
      海藤俊行
    • Organizer
      日本解剖学会総会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 皮膚感覚受容器の形態形成と機械受容に関わる分子発現の検討2013

    • Author(s)
      海藤俊行
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県高松市サンポートホール高松・かがわ国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Immunoelectron Microscopic Study of N-cadherin in the Mechanoreceptors of Human Skin2012

    • Author(s)
      Toshiyuki Kaidoh, Toshio Kameie
    • Organizer
      14th International Congress of Hitochemistry and Cytochemistry
    • Place of Presentation
      Kyoto, Japan (Kyoto International Conference Center)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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