Role of membrane potential in phagocytes
| Project/Area Number |
24590277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Osaka University |
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Principal Investigator |
Okochi Yoshifumi 大阪大学, 医学(系)研究科(研究院), 助教 (90435818)
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| Co-Investigator(Renkei-kenkyūsha) |
Umemoto Eiji 大阪大学, 大学院医学系研究科, 准教授 (90452440)
Sakimura kenji 新潟大学, 脳研究所, 教授 (40162325)
Okamura Yasushi 大阪大学, 大学院医学系研究科, 教授 (80201987)
Tsutsui Hidekazu 北陸先端科学技術大学院大学, 准教授 (30392038)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プロトンチャネル / 炎症 / 好中球 / 脱顆粒 / 貪食細胞 / 活性酸素 / pH / 膜電位 / エキソサイトーシス / 走化性 |
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| Outline of Final Research Achievements |
Voltage-gated proton channel regulates intracellular pH and membrane potential in phagocytes. We investigated the function of proton channel in neutrophils that are important immune cell in host defense. We found that proton channel negatively regulates the release of azurophil granules in neutrophils, which contain myeloperoxidase producing hypochlorous acid and degradative enzymes. We also found that proton channel deficient mice exhibit severer inflammation in lung than wild type mice upon fungal infection. These results suggest that proton channel suppresses inflammation through the inhibition of the granule release in neutrophils.
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Report
(5 results)
Research Products
(19 results)
