| Project/Area Number |
24590290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kio University |
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Principal Investigator |
SAKATA Susumu 畿央大学, 健康科学部, 教授 (20142383)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATANI Akira 奈良教育大学, 教育学部, 教授 (70116284)
NISHII Yasue 畿央大学, 健康科学部, 助手 (50461207)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 2型糖尿病 / 心不全 / 自発的運動 / OLETF / 長寿遺伝子 / 心機能 / インスリン抵抗性 / SERCA / 遺伝子発現 / ２型糖尿用 / アディポサイトカイン / インスリン / 運動パフォーマンス / ２型糖尿病 |
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| Outline of Final Research Achievements |
The aim of this study was to examine whether voluntary wheel-running (WR) suppress development of diabetes mellitus (DM) and improve heart failure in a type 2 DM model rat OLETF. Five-week-old OLETF rats were housed either in cages equipped with wheels (OLETF-WR) or in standard cages (OLETF-SED) for 16 months. Blood glucose (BG) and Hb A1c were higher in OLETF-SED rats than in OLETF-WR and LETO rats. Echocardiography and left ventricle (LV) catheterization clarified that OLETF-SED rats have decreased maximal LV pressure, decreased ±dP/dt and slower LV relaxation as compared with OLETF-WR and LETO rats. In addition, LV of OLETF-SED rats showed down-regulated SERCA2a expression and increased collagen fibers. These results indicate that long-term WR can suppress development of heart failure in OLETF rats. Relationship between such cardiac functions and DM- or Surtuin-related gene expression, estimated by DNA microarray, is under examination.
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