Does Surtuin gene expression, upregulated by voluntary exercise, improve type 2 DM-induced heart failure?
Project/Area Number |
24590290
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Kio University |
Principal Investigator |
SAKATA Susumu 畿央大学, 健康科学部, 教授 (20142383)
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Co-Investigator(Kenkyū-buntansha) |
NAKATANI Akira 奈良教育大学, 教育学部, 教授 (70116284)
NISHII Yasue 畿央大学, 健康科学部, 助手 (50461207)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
Keywords | 2型糖尿病 / 心不全 / 自発的運動 / OLETF / 長寿遺伝子 / 心機能 / インスリン抵抗性 / SERCA / 遺伝子発現 / 2型糖尿用 / アディポサイトカイン / インスリン / 運動パフォーマンス / 2型糖尿病 |
Outline of Final Research Achievements |
The aim of this study was to examine whether voluntary wheel-running (WR) suppress development of diabetes mellitus (DM) and improve heart failure in a type 2 DM model rat OLETF. Five-week-old OLETF rats were housed either in cages equipped with wheels (OLETF-WR) or in standard cages (OLETF-SED) for 16 months. Blood glucose (BG) and Hb A1c were higher in OLETF-SED rats than in OLETF-WR and LETO rats. Echocardiography and left ventricle (LV) catheterization clarified that OLETF-SED rats have decreased maximal LV pressure, decreased ±dP/dt and slower LV relaxation as compared with OLETF-WR and LETO rats. In addition, LV of OLETF-SED rats showed down-regulated SERCA2a expression and increased collagen fibers. These results indicate that long-term WR can suppress development of heart failure in OLETF rats. Relationship between such cardiac functions and DM- or Surtuin-related gene expression, estimated by DNA microarray, is under examination.
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Report
(4 results)
Research Products
(32 results)
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[Presentation] Voluntary exercise suppresses development of diabetes mellitus and improves exercise performance in OLETF rats
Author(s)
Sakata S, Hanaoka T, Takada Y, Okuda S, Yasui T, Washio H, Takeshita D, Iwami K, Imagita H, Minematsu A, Waki H, Nakatani A
Organizer
第91回日本生理学会大会
Place of Presentation
鹿児島大学
Related Report
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