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Involvement of prostaglandins in cognitive function induced by brain inflammation

Research Project

Project/Area Number 24590314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionInstitute for Developmental Research, Aichi Human Service Center

Principal Investigator

MAKOTO MIZUNO  愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (20345515)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脳内炎症 / 行動解析 / 発達障害
Outline of Final Research Achievements

Inflammatory process is implicated in various cognitive disorders. In this experiments, we examine prostaglandin induced during development, which are involved in cognitive functions in mice. We use lipopolysaccharide (LPS) for induction of prostaglandins. Prenatal maternal LPS exposure leads to behavioral deficits such as cognitive disorder and social disability in the offspring. After birth inhibition of prostaglandin EP2 receptor show still behavioral deficits. However, at the same time for LPS injection, inhibition of prostaglandin EP2 receptor show amelioration of behavioral abnormalities. Taken together, these results suggest that prostaglandin via prenatal brain inflammation leads to behavioral deficits in the offspring.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (3 results)

  • [Journal Article] Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders.2015

    • Author(s)
      Mizuno M, Matsumoto A, Hamada N, Ito H, Miyauchi A, Jimbo EF, Momoi MY, Tabata H, Yamagata T, Nagata K.
    • Journal Title

      J Neurochem

      Volume: 132 Issue: 1 Pages: 61-69

    • DOI

      10.1111/jnc.12943

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LIN7A Depletion Disrupts Cerebral Cortex Development, Contributing to Intellectual Disability in 12q21-Deletion Syndrome.2014

    • Author(s)
      Matsumoto A, Mizuno M, Hamada N, Nozaki Y, Jimbo EF, Momoi MY, Nagata K, Yamagata T.
    • Journal Title

      PLoS One

      Volume: 9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ErbB Inhibitors Ameliorate Behavioral Impairments of An Animal Model for Schizophrenia; Implication of Their Dopamine-Modulatory Actions.2013

    • Author(s)
      Mizuno M, Sotoyama H, Namba H, Shibuya M, Eda T, Wang R, Okubo T, Nagata K,Iwakura Y, Nawa H.
    • Journal Title

      Transl Psychiatry

      Volume: 3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Antipsychotic potential of antioxidative agents in models for schizophrenia2014

    • Author(s)
      Makoto Mizuno, Ko-ichi Nagata
    • Organizer
      FENS
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Antipsychotic potential of thalidomide in immune/inflammatory model for schizophreni2013

    • Author(s)
      Makoto Mizuno, Hiroyuki Nawa, Ko-ichi Nagata
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Antipsychotic potential of antioxidative agents in immune /inflammatory model for schizophrenia2012

    • Author(s)
      水野誠
    • Organizer
      2012年北米神経科学会
    • Place of Presentation
      アメリカ合衆国(ニューオリンズ市)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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