Involvement of prostaglandins in cognitive function induced by brain inflammation

• Project/Area Number: 24590314
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: MAKOTO MIZUNO 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (20345515)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 脳内炎症 / 行動解析 / 発達障害

Outline of Final Research Achievements

Inflammatory process is implicated in various cognitive disorders. In this experiments, we examine prostaglandin induced during development, which are involved in cognitive functions in mice. We use lipopolysaccharide (LPS) for induction of prostaglandins. Prenatal maternal LPS exposure leads to behavioral deficits such as cognitive disorder and social disability in the offspring. After birth inhibition of prostaglandin EP2 receptor show still behavioral deficits. However, at the same time for LPS injection, inhibition of prostaglandin EP2 receptor show amelioration of behavioral abnormalities. Taken together, these results suggest that prostaglandin via prenatal brain inflammation leads to behavioral deficits in the offspring.

Research Products

• [Journal Article] Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders. (2015)
  • Author(s): Mizuno M, Matsumoto A, Hamada N, Ito H, Miyauchi A, Jimbo EF, Momoi MY, Tabata H, Yamagata T, Nagata K.
  • Journal Title: J Neurochem Volume: 132 Issue: 1 Pages: 61-69
  • DOI: 10.1111/jnc.12943
  • Peer Reviewed / Open Access
• [Journal Article] LIN7A Depletion Disrupts Cerebral Cortex Development, Contributing to Intellectual Disability in 12q21-Deletion Syndrome. (2014)
  • Author(s): Matsumoto A, Mizuno M, Hamada N, Nozaki Y, Jimbo EF, Momoi MY, Nagata K, Yamagata T.
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed / Open Access
• [Journal Article] ErbB Inhibitors Ameliorate Behavioral Impairments of An Animal Model for Schizophrenia; Implication of Their Dopamine-Modulatory Actions. (2013)
  • Author(s): Mizuno M, Sotoyama H, Namba H, Shibuya M, Eda T, Wang R, Okubo T, Nagata K,Iwakura Y, Nawa H.
  • Journal Title: Transl Psychiatry Volume: 3
  • Peer Reviewed
• [Presentation] Antipsychotic potential of antioxidative agents in models for schizophrenia (2014)
  • Author(s): Makoto Mizuno, Ko-ichi Nagata
  • Organizer: FENS
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-07-05 – 2014-07-09
• [Presentation] Antipsychotic potential of thalidomide in immune/inflammatory model for schizophreni (2013)
  • Author(s): Makoto Mizuno, Hiroyuki Nawa, Ko-ichi Nagata
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] Antipsychotic potential of antioxidative agents in immune /inflammatory model for schizophrenia (2012)
  • Author(s): 水野誠
  • Organizer: ２０１２年北米神経科学会
  • Place of Presentation: アメリカ合衆国（ニューオリンズ市）