Involvement of prostaglandins in cognitive function induced by brain inflammation
| Project/Area Number |
24590314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
MAKOTO MIZUNO 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (20345515)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脳内炎症 / 行動解析 / 発達障害 |
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| Outline of Final Research Achievements |
Inflammatory process is implicated in various cognitive disorders. In this experiments, we examine prostaglandin induced during development, which are involved in cognitive functions in mice. We use lipopolysaccharide (LPS) for induction of prostaglandins. Prenatal maternal LPS exposure leads to behavioral deficits such as cognitive disorder and social disability in the offspring. After birth inhibition of prostaglandin EP2 receptor show still behavioral deficits. However, at the same time for LPS injection, inhibition of prostaglandin EP2 receptor show amelioration of behavioral abnormalities. Taken together, these results suggest that prostaglandin via prenatal brain inflammation leads to behavioral deficits in the offspring.
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Report
(5 results)
Research Products
(6 results)
