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Exploration of anti-arrhythmic drugs acting on RyR2 using myocardium and cultured cells.

Research Project

Project/Area Number 24590331
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionJuntendo University

Principal Investigator

KUREBAYASHI Nagomi  順天堂大学, 医学部, 准教授 (50133335)

Co-Investigator(Renkei-kenkyūsha) MURAYAMA Takashi  順天堂大学, 医学部, 准教授 (10230012)
MORIMOTO Sachio  九州大学, 医学部, 准教授 (50202362)
NAKAZATO Yuji  順天堂大学, 医学部, 教授 (30266035)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsリアノジン受容体 / 不整脈 / カルシウム / カテコラミン誘発性多型性心室頻拍 / 抗不整脈薬 / 心臓 / 心筋 / 筋小胞体 / ライブイメージング / Ca2+遊離
Outline of Final Research Achievements

The agents acting on type 2 ryanodine receptor (RyR2) are expected to be good anti-arrhythmic and/or preventive drugs. In this study, we developed experimental systems that are useful for search of anti-arrhythmic drugs acting on RyR2; one is arrhythmogenic myocardium and the other is a cultured cell system expressing recombinant RyR2 molecules.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2015 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (11 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice.2014

    • Author(s)
      Odagiri, F., H. Inoue, M. Sugihara, T. Suzuki, T. Murayama, T. Shioya, M. Konishi, Y. Nakazato, H. Daida, T. Sakurai, S. Morimoto, N. Kurebayashi
    • Journal Title

      PLoS One

      Volume: 9 Issue: 7 Pages: e101838-e101838

    • DOI

      10.1371/journal.pone.0101838

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assembly of the cochlear gap junction macromolecular complex requires connexin 26.2014

    • Author(s)
      Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K.
    • Journal Title

      J Clin Invest,

      Volume: 124 Issue: 4 Pages: 1598-1607

    • DOI

      10.1172/jci67621

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] キーワード解説:カルシウム・膜電位イメージング.2014

    • Author(s)
      呉林なごみ
    • Journal Title

      日本薬理学雑誌

      Volume: 143 Pages: 45-46

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model2014

    • Author(s)
      Sugihara M, Odagiri F, Suzuki T, Murayama T, Nakazato Y, Unuma K, Yoshida K, Daida H, Sakurai T, Morimoto S, Kurebayashi N.
    • Journal Title

      PLoS One

      Volume: 8(1) Issue: 1 Pages: e55514-e55514

    • DOI

      10.1371/journal.pone.0055514

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] キーワード解説:カルシウム・膜電位イメージング2014

    • Author(s)
      呉林なごみ
    • Journal Title

      日本薬理学雑誌

      Volume: 143 Pages: 45-46

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-Trisphosphate receptor regulates replication, differentiation, infectivity, and virulence of the parasitic protist Trypanosoma cruzi2013

    • Author(s)
      Hashimoto M
    • Journal Title

      Mol Microbiology

      Volume: 87(6) Issue: 6 Pages: 1133-50

    • DOI

      10.1111/mmi.12155

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy2012

    • Author(s)
      Suzuki T, Shioya T, Murayama T, Sugihara M, Odagiri F, Nakazato Y, Nishizawa H, Chugun A, Sakurai T, Daida H, Morimoto S, Kurebayashi N
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 4 Pages: e35353-e35353

    • DOI

      10.1371/journal.pone.0035353

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 筋小胞体のCa2+放出機構の最近の進歩2012

    • Author(s)
      呉林なごみ, 村山尚
    • Journal Title

      生体の科学

      Volume: 63 Pages: 374-375

    • Related Report
      2012 Research-status Report
  • [Presentation] 2型リアノジン受容体の不整脈原性変異はCICR活性とCa2+ 動態にどのような影響を及ぼすか?2015

    • Author(s)
      呉林なごみ, 村山尚, 太田亮作, 山下富義, 鈴木純二, 金丸和典, 飯野正光, 櫻井隆
    • Organizer
      第88回 日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of arrhythmogenic mutations on Ca2+-induced Ca2+ release activities of type 2 ryanodine receptors.2015

    • Author(s)
      Kurebayashi, N., T. Murayama, J. Suzuki, K. Kanemaru, M. Iino, T. Sakurai
    • Organizer
      Biophysical society, 59th Annual Meeting
    • Place of Presentation
      ボルチモア、アメリカ合衆国
    • Year and Date
      2015-02-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of MH and CCD mutations in the central region on RyR1 channels.2015

    • Author(s)
      Takashi Murayama, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Junji Suzuki, Kazunori Kanemaru, Katsuji Oguchi, Masamitsu Iino, and Takashi Sakurai
    • Organizer
      Biophysical Society 59th Annual Meeting
    • Place of Presentation
      ボルチモア、アメリカ合衆国
    • Year and Date
      2015-02-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 心筋型リアノジン受容体(RyR2)不整脈原性変異のCa2+ 動態とCICR活性に対する効果2014

    • Author(s)
      呉林なごみ, 村山尚, 太田亮作, 山下富義, 鈴木純二, 金丸和典, 飯野正光, 櫻井隆
    • Organizer
      第24回 日本循環薬理学会
    • Place of Presentation
      山形テルサ、山形市
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 心室性不整脈を誘発する2型リアノジン受容体変異体のCa2+遊離の特性2014

    • Author(s)
      呉林なごみ 村山尚 鈴木純二 金丸和典 飯野正光 櫻井隆
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
  • [Presentation] 不整脈原性2型リアノジン受容体のCICR特性2014

    • Author(s)
      呉林なごみ 村山尚 鈴木純二 金丸和典 飯野正光 櫻井隆
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] Divergent effects of disease associated mutations on type 2 ryanodine receptor channel.2014

    • Author(s)
      Kurebayashi, N Murayama, T Uehara, A Yasukochi, M Sakura,i T
    • Organizer
      58th Biophysical Society Annual Meeting
    • Place of Presentation
      サンフランシスコ、米国
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of candesartan on progression of electrical remodeling in the hearts of inherited DCM model mice2014

    • Author(s)
      Nagomi Kurebayashi, Fiminori Odagiri, Hana Inoue, Masami Sugihara, Takeshi Suzuki, Takashi Murayama, Takao Shioya, Masato Konishi, Yuji Nakazato, Hiroyuki Daida, Takashi Sakurai, Sachio Morimoto,
    • Organizer
      17th World Congress of Pharmacology
    • Place of Presentation
      ケープタウン、南アフリカ共和国
    • Related Report
      2013 Research-status Report
  • [Presentation] 拡張型心筋症モデルマウス心臓の電気的リモデリングに対するカンデサルタンの効果2013

    • Author(s)
      呉林なごみ, 小田切史徳, 杉原匡美, 鈴木剛, 井上華, 村山尚, 塩谷孝雄, 小西真人, 中里祐二, 代田浩之, 櫻井隆, 森本幸生
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 遺伝性拡張型心筋症における無症候期、突然死危険期、破綻期と、これらを左右する因子2013

    • Author(s)
      呉林なごみ
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京 船堀
    • Related Report
      2012 Research-status Report
  • [Presentation] FFECTS OF ANGIOTENSIN II RECEPTOR BLOCKER ON THE PROGRESSION OF ELECTRICAL REMODELING IN HEARTS OF INHERITED DCM MODEL MICE.2013

    • Author(s)
      Odagiri F, Inoue H, Sugihara M, Suzuki T, Murayama T, Shioya T, Konishi M, Nakazato Y, Daida H, Sakurai T, Morimoto S, Kurebayashi N
    • Organizer
      57th Biophysical Society Annual Meeting Philadelphia
    • Place of Presentation
      フィラデルフィア
    • Related Report
      2012 Research-status Report
  • [Book] 不整脈学2012

    • Author(s)
      呉林 なごみ
    • Publisher
      南江堂
    • Related Report
      2012 Research-status Report
  • [Remarks] 順天堂大学大学院 細胞・分子薬理学 ホームページ

    • URL

      http://pharmacology.sakura.ne.jp/index.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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