Exploration of anti-arrhythmic drugs acting on RyR2 using myocardium and cultured cells.
| Project/Area Number | 24590331 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURAYAMA Takashi 順天堂大学, 医学部, 准教授 (10230012)
MORIMOTO Sachio 九州大学, 医学部, 准教授 (50202362)
NAKAZATO Yuji 順天堂大学, 医学部, 教授 (30266035)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed(Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost : ¥4,100,000、Indirect Cost : ¥1,230,000)
Fiscal Year 2014 : ¥1,690,000 (Direct Cost : ¥1,300,000、Indirect Cost : ¥390,000)
Fiscal Year 2013 : ¥1,040,000 (Direct Cost : ¥800,000、Indirect Cost : ¥240,000)
Fiscal Year 2012 : ¥2,600,000 (Direct Cost : ¥2,000,000、Indirect Cost : ¥600,000)
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| Keywords | リアノジン受容体 / 不整脈 / カルシウム / カテコラミン誘発性多型性心室頻拍 / 抗不整脈薬 / 心臓 / 心筋 / 筋小胞体 / ライブイメージング / Ca2+遊離 |
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| Outline of Final Research Achievements |
The agents acting on type 2 ryanodine receptor (RyR2) are expected to be good anti-arrhythmic and/or preventive drugs. In this study, we developed experimental systems that are useful for search of anti-arrhythmic drugs acting on RyR2; one is arrhythmogenic myocardium and the other is a cultured cell system expressing recombinant RyR2 molecules.
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Report
(4results)
Research Products
(20results)
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[Journal Article] Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice.2014
Author(s)
Odagiri, F., H. Inoue, M. Sugihara, T. Suzuki, T. Murayama, T. Shioya, M. Konishi, Y. Nakazato, H. Daida, T. Sakurai, S. Morimoto, N. Kurebayashi
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model2014
Author(s)
Sugihara M, Odagiri F, Suzuki T, Murayama T, Nakazato Y, Unuma K, Yoshida K, Daida H, Sakurai T, Morimoto S, Kurebayashi N.
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Journal Title
DOI
Related Report
Peer Reviewed
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[Journal Article] Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy2012
Author(s)
Suzuki T, Shioya T, Murayama T, Sugihara M, Odagiri F, Nakazato Y, Nishizawa H, Chugun A, Sakurai T, Daida H, Morimoto S, Kurebayashi N
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Journal Title
DOI
Related Report
Peer Reviewed
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[Presentation] Effects of candesartan on progression of electrical remodeling in the hearts of inherited DCM model mice2014
Author(s)
Nagomi Kurebayashi, Fiminori Odagiri, Hana Inoue, Masami Sugihara, Takeshi Suzuki, Takashi Murayama, Takao Shioya, Masato Konishi, Yuji Nakazato, Hiroyuki Daida, Takashi Sakurai, Sachio Morimoto,
Organizer
17th World Congress of Pharmacology
Place of Presentation
ケープタウン、南アフリカ共和国
Related Report
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[Presentation] 拡張型心筋症モデルマウス心臓の電気的リモデリングに対するカンデサルタンの効果2013
Author(s)
呉林なごみ, 小田切史徳, 杉原匡美, 鈴木剛, 井上華, 村山尚, 塩谷孝雄, 小西真人, 中里祐二, 代田浩之, 櫻井隆, 森本幸生
Organizer
第86回日本薬理学会年会
Place of Presentation
福岡
Related Report
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[Presentation] FFECTS OF ANGIOTENSIN II RECEPTOR BLOCKER ON THE PROGRESSION OF ELECTRICAL REMODELING IN HEARTS OF INHERITED DCM MODEL MICE.2013
Author(s)
Odagiri F, Inoue H, Sugihara M, Suzuki T, Murayama T, Shioya T, Konishi M, Nakazato Y, Daida H, Sakurai T, Morimoto S, Kurebayashi N
Organizer
57th Biophysical Society Annual Meeting Philadelphia
Place of Presentation
フィラデルフィア
Related Report
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