Role of a novel lysophospholipase in phospholipid metabolism
| Project/Area Number |
24590367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
HIRABAYASHI Tetsuya 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (90345025)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ホスホリパーゼ / コリン / グリセロホスホコリン / 肝臓 / 脂肪組織 / 脂質代謝 / 褐色化 / リゾホスホリパーゼ |
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| Outline of Final Research Achievements |
We have discovered that a novel lysophospholipase, iPLA2θ, is essential for the mobilization of free choline from the major membrane phospholipid, phoshatidylcholine. Mice deficient in this enzyme cannot utilize sufficient endogenous free choline in the liver, which leads to a shortage of hepatic methyl donors, betaine and S-adenosylmethionine. Our results also indicate that iPLA2θ is required for normal lipid and glucose metabolism.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] New insight into PLA2s: from outside and inside2015
Author(s)
Murakami M, Taketomi Y, Sato H, Miki Y, Hirabayashi T, Yamamoto K
Organizer
The 6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015) from bench to translational medicine
Place of Presentation
京王プラザホテル（東京都新宿区）
Year and Date
2015-02-11
Related Report
Invited
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