A strategy of RAGE shedding is promising for conquering diabetic vascular complications

• Project/Area Number: 24590375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: YAMAMOTO Yasuhiko 金沢大学, 医学系, 准教授 (20313637)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Hiroshi 金沢大学, その他部局等, 理事 (00115198)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: RAGE / 可溶型RAGE / shediing / shedding

Outline of Final Research Achievements

Receptor for advanced glycation end-products (RAGE) is considered linked to the onset and progression of diabetic vascular complications and atherosclerosis. By focusing on target therapies against RAGE, one potentially useful strategy is the conversion of the membrane-bound form of RAGE (mRAGE) to soluble isoform (sRAGE). The ectodomain shedding can increase the sRAGE level and concomitantly decrease mRAGE expression, potentially leading to the prevention and the attenuation of the diabetic vascular diseases. In this study, we screened drug and chemical libraries and identified useful candidates to mediate the ectodomain shedding of RAGE. Our finding will provide promising drugs for treating diabetic patients.

Research Products

• [Journal Article] Enzymatic and non-enzymatic post-translational modifications linking diabetes and heart disease. (2015)
  • Author(s): Yamamoto Y, Yamamoto H
  • Journal Title: J Diabetes Invest Volume: 6(1) Issue: 1 Pages: 16-17
  • DOI: 10.1111/jdi.12248
  • NAID: 120005821074
  • Peer Reviewed / Open Access
• [Journal Article] Emphysema requires the receptor for advanced glycation end products triggering on structural cells. (2015)
  • Author(s): Waseda K, Miyahara N, Taniguchi A, Kurimoto E, Ikeda G, Koga H, Fujii U, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A.
  • Journal Title: Am J Respir Cell Mol Biol Volume: 52(4) Issue: 4 Pages: 482-491
  • DOI: 10.1165/rcmb.2014-0027oc
  • Peer Reviewed
• [Journal Article] RAGE mediates the interactivation of nAChRs in sympathetic neurons during high glucose conditions. (2015)
  • Author(s): Chandna AR, Baskaran MN, Chang C, Pennington PR, Mousseau DD, Yamamoto Y, Campanucci VA.
  • Journal Title: Eur J Neurosci Volume: 41(3) Issue: 3 Pages: 341-351
  • DOI: 10.1111/ejn.12795
  • Peer Reviewed
• [Journal Article] Gadd34 regulates liver regeneration in hepatic steatosis. (2015)
  • Author(s): Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H.
  • Journal Title: Hepatology Volume: 61(4) Issue: 4 Pages: 1343-1356
  • DOI: 10.1002/hep.27619
  • Peer Reviewed / Open Access
• [Journal Article] Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism (2014)
  • Author(s): Toda M, D'Alessandro-Gabazza CN, Takagi T, Chelakkot-Govindalayathila AL, Taguchi O, Roeen Z, Munesue S, Yamamoto Y, Yamamoto H, Gabazza EC, Morser J.
  • Journal Title: Allergology International Volume: 63 Issue: 1 Pages: 57-66
  • DOI: 10.2332/allergolint.13-OA-0595
  • NAID: 130004873109
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] HMGB1 and RAGE mediate airway sensitization to inhaled allergens. (2014)
  • Author(s): Ullah MA, Loh Z, Gan WJ, Zhang V, Yang H, Li JH, Yamamoto Y, Schmidt AM, Armour CL, Hughes JM, Phipps S, Sukkar MB
  • Journal Title: J Allergy Clin Immun Volume: Epub ahead of print Issue: 2 Pages: 440-450
  • DOI: 10.1016/j.jaci.2013.12.1035
  • Peer Reviewed
• [Journal Article] Maltitol endows foods with lower 3-deoxyglucosone content and less RAGE agonism as a sweetener against sucrose. (2014)
  • Author(s): Kuretani A, Kawamura R, Munesue S, Yamamoto Y, Honda J, Yamamoto H.
  • Journal Title: Glycative Stress Res Volume: 1(2) Pages: 25-31
  • NAID: 40021134946
  • Peer Reviewed / Open Access
• [Journal Article] Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction. (2014)
  • Author(s): OkumaY, Liu K, Wake H, Liu R, Nishimura Y, Zhong H, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi HK, Mori S, Nishibori M.
  • Journal Title: Neuropharmacology Volume: 85 Pages: 18-26
  • DOI: 10.1016/j.neuropharm.2014.05.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] cAMP ameliorates inflammation in macrophages by modulation of receptor for advanced glycation end-products. (2014)
  • Author(s): Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han H, Watanabe T, Sato H, Yamamoto H.
  • Journal Title: Biochem J Volume: 463(1) Issue: 1 Pages: 75-82
  • DOI: 10.1042/bj20140084
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Longistatin secreted with tick saliva blocks RAGE. (2014)
  • Author(s): Anisuzzaman, Hatta T, Miyoshi T, Mtsubayashi M, Islam MK, Alim MA, Anas MA, Hasan MM, Matsumoto Y, Yamamoto Y, Yamamoto H, Fujisaki K, Tsuji N.
  • Journal Title: J Clin Invest Volume: 124(10) Pages: 4429-4444
  • Peer Reviewed / Open Access
• [Journal Article] Expression of RAGE by tumor macrophages promotes angiogenesis in gliomas. (2014)
  • Author(s): Chen X, Zhang L, Zhang IY, Liang J, Wang H, Ouyang M, Wu S, da Fonseca ACC, Weng L, Yamamoto Y, Yamamoto H, Natarajan R, Badie B.
  • Journal Title: Cancer Res Volume: 74(24) Pages: 7285-7297
  • Peer Reviewed
• [Journal Article] Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury. (2014)
  • Author(s): Sakai S, Tajima H, Miyashita T, Nakanuma SI, Makino I, Hayashi H, Nakagawara H, Kitagawa H, Fushida S, Fujimura T, Saito H, Munesue S, Yamamoto Y, Ohta T.
  • Journal Title: Dig Dis Sci Volume: 59(4) Issue: 4 Pages: 787-794
  • DOI: 10.1007/s10620-013-2963-8
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. (2014)
  • Author(s): Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H, Kasashima S, Kawashima A, Nakanuma Y.
  • Journal Title: J Clin Pathol Volume: 67(5) Issue: 5 Pages: 396-402
  • DOI: 10.1136/jclinpath-2013-201815
  • NAID: 120005469783
  • Peer Reviewed / Open Access
• [Journal Article] Role of cell-cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes (2013)
  • Author(s): Kohka Takahashi H, Sadamori H, Liu K, Wake H, Mori S, Yoshino T, Yamamoto Y, Yamamoto H, Nishibori M
  • Journal Title: European Journal of Pharmacology Volume: 701(1-3) Issue: 1-3 Pages: 194-202
  • DOI: 10.1016/j.ejphar.2012.11.058
  • Peer Reviewed
• [Journal Article] Receptor for advanced glycation end-products (RAGE) regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of Toll-like receptor 2 (2013)
  • Author(s): Monden M, Koyama H, Otsuka Y, Morioka T, Mori K, Shoji T, Mima Y, Motoyama K, Fukumoto S, Shioi A, Emoto M, Yamamoto H, Nishizawa Y, Kurajoh M, Tetsuya Yamamoto T, Inaba M
  • Journal Title: Ｄｉａｂｅｔｅｓ Volume: 62 Issue: 2 Pages: 478-489
  • DOI: 10.2337/db11-1116
  • Peer Reviewed
• [Journal Article] Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreaticβ-cell failure in type 2 diabetes. (2013)
  • Author(s): Han D, Yamamoto Y, Munesue S, Motoyoshi S, Saito H, Win MT, Watanabe T, Tsuneyama K, Yamamoto H.
  • Journal Title: Genes Cells. Volume: 18(4) Issue: 4 Pages: 302-14
  • DOI: 10.1111/gtc.12036
  • Peer Reviewed
• [Journal Article] Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells. (2013)
  • Author(s): Takeuchi A, Yamamoto Y, Munesue S, Harashima A, Watanabe T, Yonekura H, Yamamoto H, Tsuchiya H.
  • Journal Title: Cancer Sci. Volume: 104(6) Issue: 6 Pages: 740-749
  • DOI: 10.1111/cas.12133
  • NAID: 120005830605
  • Peer Reviewed
• [Journal Article] Validated liquid culture monitoring system for lifespan extension of Caenorhabditis elegans through genetic and dietary manipulations. (2013)
  • Author(s): Myat TTW, Yamamoto Y, Munesue S, Han D, Harada S, Yamamoto H
  • Journal Title: Aging Dis Volume: 4(4) Pages: 178-185
  • Peer Reviewed
• [Journal Article] RAGE-mediated inflammation, type 2 diabetes and diabetic vascular complication. (2013)
  • Author(s): Yamamoto Y, Yamamoto H
  • Journal Title: Front Endocrinol Volume: 4 Pages: 105-105
  • Peer Reviewed
• [Journal Article] CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice. (2013)
  • Author(s): Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva YK, Salmina AB, Nishimura T, Fakhrul AAKM, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H
  • Journal Title: Mol Brain Volume: 6(1) Issue: 1 Pages: 41-41
  • DOI: 10.1186/1756-6606-6-41
  • Peer Reviewed
• [Journal Article] Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone. (2013)
  • Author(s): Kim MS, Yamamoto Y, Kim K, Kamei N, Shimada T, Liu L, Moore K, Woo JR, Shoelson SE, Lee J
  • Journal Title: PLoS ONE Volume: 8(12) Issue: 12 Pages: e82847-e82847
  • DOI: 10.1371/journal.pone.0082847
  • Peer Reviewed
• [Journal Article] Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts. (2013)
  • Author(s): Munesue S, Yamamoto Y, Urushihara R, Inomata K, Saito H, Motoyoshi S, Watanabe T, Yonekura H, Yamamoto H.
  • Journal Title: Food Funct. Volume: 4(12) Issue: 12 Pages: 1835-1842
  • DOI: 10.1039/c2fo30359k
  • NAID: 120005373515
  • Peer Reviewed
• [Journal Article] Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes. (2013)
  • Author(s): Han D, Yamamoto Y et al.
  • Journal Title: Genes Cells Volume: 18(4) Pages: 302-314
  • Peer Reviewed
• [Journal Article] Role of cell-cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes. (2013)
  • Author(s): Kohka Takahashi H, Sadamori H, Liu K, Wake H, Mori S, Yoshino T, Yamamoto Y et al.
  • Journal Title: Eur J Pharmacol Volume: 701(1-3) Pages: 194-202
  • Peer Reviewed
• [Journal Article] Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of toll-like receptor 2. (2013)
  • Author(s): Monden M, Koyama H, Otsuka Y, Morioka T, Mori K, Shoji T, Mima Y, Motoyama K, Fukumoto S, Shioi A, Emoto M, Yamamoto Y, et al,
  • Journal Title: Diabetes Volume: 62(2) Pages: 478-489
  • Peer Reviewed
• [Journal Article] CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. (2012)
  • Author(s): Kitade H, Sawamoto H, Nagashimada M, Inoue H, Yamamoto Y, et al.
  • Journal Title: Diabetes Volume: 61(7) Pages: 1680-1690
  • Peer Reviewed
• [Journal Article] RAGE mediates vascular injury and delayed neuronal death after global cerebral ischemia. (2012)
  • Author(s): Kamide T, Kitao Y, Takeichi T, Okada A, Mohri H, Schmidt AM, Kawano T, Munesue S, Yamamoto Y, et al.
  • Journal Title: Neurochem Int Volume: 60(3) Pages: 220-228
  • Peer Reviewed
• [Journal Article] Controlling RAGE to conquer diabetic vascular complications. (2012)
  • Author(s): Yamamoto Y, Yamamoto H
  • Journal Title: J Diabetes Invest Volume: 3(2) Pages: 107-114
  • Peer Reviewed
• [Journal Article] Diabetes alters the subsets of mouse endothelial progenitor cells that reside in blood, bone marrow and spleen. (2012)
  • Author(s): Saito H, Yamamoto Y, Yamamoto H.
  • Journal Title: Am J Physiol Cell Physiol Volume: 302(6)
  • Peer Reviewed
• [Journal Article] Anti-HMGB1 monoclonal antibody ameliorates fluid percussion-induced brain injury in rats through protection of BBB and inhibition of inflammatory responses. (2012)
  • Author(s): Okuma Y, Liu K, Wake H, Zhang J, Maruo T, Date I, Yoshino T, Ohtsuka A, Otani N, Tomura S, Shima K, Yamamoto Y, et al.
  • Journal Title: Ann Neurol Volume: 71(3) Pages: 373-384
  • Peer Reviewed
• [Journal Article] Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury. (2012)
  • Author(s): Yamamoto Y, Yamamoto H
  • Journal Title: Kidney Int Volume: 82(7) Pages: 733-735
  • Peer Reviewed
• [Journal Article] Advanced end products and their receptors as risk factors for aging. (2012)
  • Author(s): Nagai R, Jinno M, Ichihashi M, Koyama H, Yamamoto Y, Yonei Y
  • Journal Title: Anti-aging Med Volume: 9(4) Pages: 108-113
  • Peer Reviewed
• [Journal Article] Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-beta1-42 uptake into mouse brain. (2012)
  • Author(s): Sugihara T, Munesue S, Yamamoto Y, et al.
  • Journal Title: J Alzheimer’s Dis Volume: 8(3) Pages: 709-720
  • Peer Reviewed
• [Journal Article] Regulation of RAGE for attenuating progression of diabetic vascular complications. (2012)
  • Author(s): Thu Thu Win M, Yamamoto Y, et al.
  • Journal Title: Exp Diabetes Res Volume: 2012 Pages: 894605-894605
  • Peer Reviewed
• [Presentation] Antitumor Effect Of Zaltoprofen For Pigmented Villonodular Synovitis Cells With PPARγ Activation (2015)
  • Author(s): Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Nishida H, Tanzawa Y, Kimura H, Yamamoto Y, Tsuchiya H.
  • Organizer: 2015 AAOS Annual Meeting
  • Place of Presentation: ラスベガス
  • Year and Date: 2015-03-24
• [Presentation] 代謝内分泌からみたスンクスのおもしろさ (2015)
  • Author(s): 山本靖彦
  • Organizer: 第9回スンクス研究会
  • Place of Presentation: 神戸女子大学ポートアイランドキャンパス
  • Year and Date: 2015-03-20
  • Invited
• [Presentation] Functional interplay between the leukotriene B4 receptor BLT1 and RAGE (2015)
  • Author(s): Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Sakaguchi M, Yokomizo T.
  • Organizer: 1.6th International conference on phospholipase A2 and lipid mediators (PLM2015)
  • Place of Presentation: 東京
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] メイラード反応による糖化ストレスと生活習慣病 (2014)
  • Author(s): 山本靖彦
  • Organizer: 第49回日本食生活学会
  • Place of Presentation: ITビジネスプラザ武蔵（金沢）
  • Year and Date: 2014-11-29
  • Invited
• [Presentation] 脳血管保護因子としての内在性分泌型RAGEの機能解析 (2014)
  • Author(s): 清水有、山本靖彦、原島愛、棟居聖一、林康彦、北尾康子、堀修、山本博
  • Organizer: 第24回日本メイラード学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2014-11-07 – 2014-11-08
• [Presentation] 内在性分泌型RAGEの血液脳関門を越えてデコイ受容体としての神経細胞保護作用を発揮する (2014)
  • Author(s): 清水有、山本靖彦、原島愛、棟居聖一、大石正博、林康彦、北尾康子、堀修、山本博
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2014-10-18
• [Presentation] 糖化反応と細胞応答さらにその制御系 (2014)
  • Author(s): 山本靖彦
  • Organizer: 第9回グルコサミン研究会・研修会
  • Place of Presentation: 順天堂大学医学部
  • Year and Date: 2014-08-08
  • Invited
• [Presentation] 膵β細胞のレプチンシグナル不全はRAGEの発現誘導を介して膵β細胞疲弊に関わる (2014)
  • Author(s): 山本靖彦、韓冬、棟居聖一、山本博
  • Organizer: 第14回日本抗加齢医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-06
• [Presentation] 糖尿病網膜症の病態（基礎/内科から） (2013)
  • Author(s): 山本靖彦
  • Organizer: 第19回日本糖尿病眼学会総会
  • Place of Presentation: 神戸（国際会議場）
  • Invited
• [Presentation] Absence of mature adipocytes and adipocyte precursor cells in mesentery of Suncus murinus (2013)
  • Author(s): Yasuhiko Yamamoto, Yi Shuang-Qin, Hidehito Saito, Munesue Seiichi, Ozaki Noriyuki, Hiroshi Yamamoto
  • Organizer: 73th Scientific sessions of American Diabetes Association
  • Place of Presentation: Chicago, IL, U.S.A.（Convention Ctr）
• [Presentation] Suncus murinus is a unique animal model lacking mesenteric fat and adipocyte progenitor cells (2013)
  • Author(s): Yasuhiko Yamamoto, Yi Shuang-Qin, Hidehito Saito, Munesue Seiichi, Ozaki Noriyuki, Hiroshi Yamamoto
  • Organizer: 第56回日本糖尿病学会年次学術総会
  • Place of Presentation: 熊本（ホテル日航熊本等）
• [Presentation] レプチンシグナル不全はRAGEの発現誘導を介して膵β細胞の糖脂肪毒性を増強する (2013)
  • Author(s): 韓冬、山本靖彦、棟居聖一、常山幸一、山本博
  • Organizer: 第56回日本糖尿病学会年次学術総会
  • Place of Presentation: 熊本（ホテル日航熊本等）
• [Presentation] Possible novel strategy of peroxisome proliferator-activated receptor gamma activation for pigmented villonodular synovitis (2013)
  • Author(s): Akihiko Takeuchi, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Hideji Nishida, Yoshikazu Tanzawa, Hiroaki Kimura, Yasuhiko Yamamoto, Hiroyuki Tsuchiya
  • Organizer: American Academy of Orthopaedic Surgeons Annual Meeting
  • Place of Presentation: Chicago, IL, U.S.A.（Convention Ctr）
• [Presentation] A feasible liquid culture assay for monitoring C. elegans lifespan by genetic, dietary and pharmacological interventions (2013)
  • Author(s): Thu Thu Win Myat, Yasuhiko Yamamoto, Shinichi Harada, Hiroshi Yamamoto
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜（国際会議場）
• [Presentation] 食品由来AGEによるAGE-RAGEシグナル阻害機構の解析 (2013)
  • Author(s): 棟居聖一、山本靖彦、漆原涼太、齋藤英仁、本吉創、渡邉琢夫、山本博
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜（国際会議場）
• [Presentation] 内在性分泌型RAGEの脳血管保護因子としての機能の解明 (2013)
  • Author(s): 清水有、山本靖彦、棟居聖一、原島愛、林康彦、濱田潤一郎、山本博
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜（国際会議場）
• [Presentation] Low-molecular weight heparin inhibits human fibrosarcoma cell proliferation, migration and invasion by blocking RAGE signaling (2013)
  • Author(s): 原島愛、武内章彦、山本靖彦、棟居聖一、山本博
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜（国際会議場）
• [Presentation] 低分子ヘパリンは線維肉腫細胞における後期糖化産物受容体（RAGE）を介する悪性度を抑制する (2013)
  • Author(s): 武内章彦、山本靖彦、原島愛、棟居聖一、山本博、土屋弘行
  • Organizer: 第72回日本癌学会学術集会
  • Place of Presentation: 横浜（国際会議場）
• [Presentation] スンクスゲノム解析プロジェクトの始動 (2013)
  • Author(s): 城ヶ原貴通，井上直子，坂田一郎，宮戸真美，宮戸健二，金子たかね，飯田弘，織田銑一，易勤，山本靖彦，尾崎紀之，黒木陽子，野口英樹，豊田敦，藤山秋佐夫，坂井貴文
  • Organizer: 第29回日本霊長類学会・日本哺乳類学会合同大会
  • Place of Presentation: 岡山(岡山理科大学)
• [Presentation] 脳血管保護因子としての内在性分泌型RAGEの機能解析 (2013)
  • Author(s): 清水有、山本靖彦、棟居聖一、原島愛、林康彦、濱田潤一郎、山本博
  • Organizer: 第23回日本メイラード学会学術集会
  • Place of Presentation: 大阪 (ナレッジキャピタル コングレコンベンションセンター)
• [Presentation] パターン認識受容体RAGEによる病態とそれに対する創薬を考える (2013)
  • Author(s): 山本靖彦、山本博
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Invited
• [Presentation] RAGE, diabetes and its vascular complications
  • Author(s): Yasuhiko Yamamoto
  • Organizer: International Conference on Diabetes and Metabolism 2012
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] 糖化制御と未病～AGEs-RAGE系からみた未病対策
  • Author(s): 山本靖彦
  • Organizer: 第19回日本未病システム学会学術総会
  • Place of Presentation: 金沢勤労者プラザ（金沢）
  • Invited
• [Presentation] Glucotoxicityと細小血管症
  • Author(s): 山本靖彦
  • Organizer: 第27回日本糖尿病合併症学会
  • Place of Presentation: アクロス福岡（福岡）
  • Invited
• [Presentation] AGRs受容体に着目した糖化ストレス対策
  • Author(s): 山本靖彦
  • Organizer: 第2回糖化ストレス研究会
  • Place of Presentation: 東京ビックサイト（東京
  • Invited
• [Book] 10.日本食生活学会誌 (2015)
  • Author(s): 山本靖彦,棟居聖一
  • Publisher: 日本食生活学会
• [Book] 金沢大学十全医学会雑誌 (2014)
  • Author(s): 山本靖彦「
  • Publisher: 金沢大学十全医学会
• [Book] 日本薬理学会雑誌 (2014)
  • Author(s): 山本靖彦，山本博
  • Publisher: 日本薬理学会
• [Book] アンチ・エイジング医学 特集今後期待される新規バイオマーカー (2014)
  • Author(s): 山本靖彦, 後藤久典, 山本博
  • Publisher: 日本抗加齢医学会
• [Book] 日本加齢医学会雑誌 (2014)
  • Author(s): 山本靖彦、後藤久典、山本博
  • Publisher: メディカルレビュー社
• [Book] 日本薬理学会雑誌 (2014)
  • Author(s): 山本靖彦、後藤久典、山本博
  • Publisher: 日本薬理学会
• [Book] 「基礎生化学」－健康と疾患とのつながり-：「第14章 血液の機能」 (2013)
  • Author(s): 山本靖彦
  • Total Pages: 259
  • Publisher: （株）アイ・ケイコーポレーション
• [Book] 日本抗加齢医学会雑誌 アンチ・エイジング医学：AGEs受容体 (2012)
  • Author(s): 山本靖彦
  • Publisher: メディカルレビュー社
• [Book] 糖尿病腎症のすべて:RAGE, AGEs (2012)
  • Author(s): 山本靖彦，山本博
  • Publisher: 中山書店
• [Book] メディカル・サイエンス・ダイジェスト（MSD）:糖尿病合併症の成因 (2012)
  • Author(s): 斎藤英仁、山本靖彦，山本博
  • Publisher: ニューサイエンス社
• [Book] Diabetic Nephropathy, John S.D. Chan (Ed.): Significance of AGE and RAGE in diabetic nephropathy (2012)
  • Author(s): Kamal T, Yamamoto Y, Yamamoto H
  • Publisher: InTech
• [Book] 糖尿病学イラストレイテッド: 細小血管症発症の分子機構（総論） (2012)
  • Author(s): 山本靖彦，山本博
  • Publisher: 南江堂
• [Remarks] 金沢大学医薬保健研究域医学系血管分子生物学ホームページ
  • URL: http://biochem2.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学脳・肝インターフェースメディシン研究センターホームページ
  • URL: http://brainliver.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学医薬保健研究域医学系血管分子生物学ホームページ
  • URL: http://biochem2.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学医薬保健研究域脳・肝インターフェースメディシン研究センターホームページ
  • URL: http://brainliver.w3.kanazawa-u.ac.jp/#
• [Remarks] 血管分子生物学ホームページ
  • URL: http://biochem2.w3.kanazawa-u.ac.jp/
• [Patent(Industrial Property Rights)] 線維化判定方法 (2015)
  • Inventor(s): 山本靖彦 （他7名）
  • Industrial Property Rights Holder: 山本靖彦 （他7名）
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-027050
  • Filing Date: 2015-02-15
• [Patent(Industrial Property Rights)] オキシトシントランスポーター (2014)
  • Inventor(s): 山本靖彦 （他5名）
  • Industrial Property Rights Holder: 山本靖彦 （他5名）
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-255721
  • Filing Date: 2014-12-18
• [Patent(Industrial Property Rights)] オキシトシン検出のためのサンプルの前処理方法 (2014)
  • Inventor(s): 山本靖彦 （他5名）
  • Industrial Property Rights Holder: 山本靖彦 （他5名）
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-255756
  • Filing Date: 2014-12-18