| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
Intestinal epithelial cells and immune cells are known to regulate intestinal immunity, it remains unclear how these cells regulate intestinal immunity, however. We examined the double regulatory role of intestinal immunity by epithelial and immune cells, focusing on SAP-1/pp90 and CD47-SIRPα signaling systems which we have originally identified. We found that phosphorylated pp90 regulates chemokine production from epithelial cells. Moreover, we demonstrated that SIRPα expression intrinsic to dendritic cells is essential for homeostasis of dendritic cells. Our findings suggest that both SAP-1/pp90 and CD47-SIRPα signaling systems regulate intestinal immunity and their disruption is implicated in the development of inflammatory bowel disease.
|
