Functional analysis of Fanconi anemia proteins in chromosome fragile site
Project/Area Number |
24590391
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YANAGI Shigeru 東京薬科大学, 生命科学部, 教授 (60252003)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | DNA複製 / ファンコニ貧血 / DNA損傷修復 |
Outline of Final Research Achievements |
We identified several genes that are involved in DNA replication stress response by siRNA library screening. These genes are reported to function as chromatin remodeling factors, but their roles in replication stress response are not clear. One of them is FancD2 related protein (D2RP) which interacts with FANCD2. According to the functional analysis, we identified that D2RP involved in DNA damage response. However, D2RP dose not take a role in FancD2 localization following DNA replication stress.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.2013
Author(s)
Sugiura, A., Nagashima, S., Tokuyama, T., Amo, T., Matsuki, Y., Ishido, S., Kudo, Y., McBride, H.M., Fukuda, T., Matsushita, T., Inatome, R., and C Yanagi, S.
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Journal Title
Mol. Cell
Volume: 51
Issue: 1
Pages: 1-15
DOI
Related Report
Peer Reviewed
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