Comprehensive study of sulfurtransferase-knockout mice associated with insufficiency of hydrogen sulfide production
| Project/Area Number |
24590392
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO Takaaki 熊本大学, 大学院生命科学研究部, 教授 (70168392)
NAGANO Masatoshi 日本医科大学, 医学部, 講師 (60271350)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
AKIMOTO Toshio 日本医科大学, 医学部, 准教授 (30184112)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ノックアウトマウス / メルカプトピルビン酸硫黄転移酵素 / 硫化水素 / 抗酸化作用 / 不安様行動 / メルカプト乳酸システイン尿症 / セロトニン / セロトニン受容体 / 硫黄酸化物 / 不安行動 / ポリスルフィド |
|---|
| Outline of Final Research Achievements |
We produced 3-mercaptopyruvate sulfurtransferase-knockout mice as model of an inherited disease, mercaptolactate-cysteine disulfiduria which is complicated by mental retardation. No malformation was observed, however, anxiety-like behavior was significantly increased. In the brain, dopamine level was unchanged. On the other hand, levels of serotonin and 5-hydroxyindolamine were increased. The expression of serotonin type 1A receptor was not changed. On the other hand, serotonin type 2A receptor was significantly increased. The relationships of hydrogen sulfide and/or polysulfide to the pathogenesis are investigating.
|
Report
(4 results)
Research Products
(19 results)
-
-
[Journal Article] Proteome analysis for downstream targets of oncogenic KRAS--the potential participation of CLIC4 in carcinogenesis in the lung.2014
Author(s)
Okudela K, Katayama A, Woo T, Mitsui H, Suzuki T, Tateishi Y, Umeda S, Tajiri M, Masuda M, Nagahara N, Kitamura H and Ohashi K
-
Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Identification of nuclear phosphoproteins as novel tobacco markers in mouse lung tissue following short-term exposure to tobacco smoke2014
Author(s)
Niimori-Kita K, Ogino K, Mikami S, Kudoh S, Koizumi D, Kudoh N, Nakamura F, Misumi M, Shimomura T, Hasegawa K, Usui F, Nagahara N, Ito T
-
Journal Title
FEBS Open Bio
Volume: 4
Issue: 1
Pages: 746-754
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] A novel fluorescence in situ hybridization assay for synovial sarcoma.2013
Author(s)
Kato K, Tanaka M, Toyoda Y, Kigasawa H, Ohama Y, Nishi T, Okuzumi S, Kurosawa K, Aida N, Nagahara N, Tanaka Y
-
Journal Title
Pathol .Res. Pract.
Volume: 209
Issue: 5
Pages: 309-313
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] High expression and diagnostic utility of internexin alpha in clear cell sarcoma of the kidney: comparative proteomics analysis and immunohistochemical study
Author(s)
Tanaka Y, Katayama A, Inoue T, Iwafuchi H, Kishimoto H, Nakayama M, Hamazaki M, Tanaka M, Yoshida M, Ijiri R, Kitagawa N, Shinkai M, Kigasawa H, Orimo H, Nagahara N
Organizer
102nd annual meeting of United State and Canadian Academy of Pathology
Place of Presentation
Baltimore
Related Report
-
-
-
-
-
-
-
