| Project/Area Number |
24590392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Takaaki 熊本大学, 大学院生命科学研究部, 教授 (70168392)
NAGANO Masatoshi 日本医科大学, 医学部, 講師 (60271350)
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| Co-Investigator(Renkei-kenkyūsha) |
AKIMOTO Toshio 日本医科大学, 医学部, 准教授 (30184112)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ノックアウトマウス / メルカプトピルビン酸硫黄転移酵素 / 硫化水素 / 抗酸化作用 / 不安様行動 / メルカプト乳酸システイン尿症 / セロトニン / セロトニン受容体 / 硫黄酸化物 / 不安行動 / ポリスルフィド |
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| Outline of Final Research Achievements |
We produced 3-mercaptopyruvate sulfurtransferase-knockout mice as model of an inherited disease, mercaptolactate-cysteine disulfiduria which is complicated by mental retardation. No malformation was observed, however, anxiety-like behavior was significantly increased. In the brain, dopamine level was unchanged. On the other hand, levels of serotonin and 5-hydroxyindolamine were increased. The expression of serotonin type 1A receptor was not changed. On the other hand, serotonin type 2A receptor was significantly increased. The relationships of hydrogen sulfide and/or polysulfide to the pathogenesis are investigating.
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