| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We performed a genome-wide association study (GWAS) of multiple loci associated with prostate cancer susceptibility in a Japanese population and identified additional three new loci reached genome-wide significance on chromosomes 11q12, 10q26 and 3p11.2. We also identified that IRX4 (Iroquois homeobox 4) is a causative gene of the PC susceptibility locus at 5p15. Knockdown of IRX4 in prostate cancer cells enhanced their growth and IRX4 overexpression suppressed their growth, indicating the functional association of IRX4 with PC and its tumor suppressive effect. In prostate cancer diagnosis, neurotransmitter polypeptide neuropeptide-Y (NPY) had a potential as a prostate cancer biomarker polypeptide. We also found Terrestrosin D, a steroidal saponin from Tribulus terrestris L., inhibited growth and angiogenesis of prostate cancer in vitro and in vivo.
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