Genomic loci analysis associated with prostate cancer susceptibility using a genome-wide association study for the pathological diagnosis
| Project/Area Number |
24590412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kochi University |
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Principal Investigator |
FURIHATA Mutsuo 高知大学, 教育研究部医療学系, 教授 (10209158)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 前立腺癌 / がん感受性遺伝子座 / ゲノムワイド関連解析 / SNP / 免疫組織化学 / 前立腺がん |
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| Outline of Final Research Achievements |
We performed a genome-wide association study (GWAS) of multiple loci associated with prostate cancer susceptibility in a Japanese population and identified additional three new loci reached genome-wide significance on chromosomes 11q12, 10q26 and 3p11.2. We also identified that IRX4 (Iroquois homeobox 4) is a causative gene of the PC susceptibility locus at 5p15. Knockdown of IRX4 in prostate cancer cells enhanced their growth and IRX4 overexpression suppressed their growth, indicating the functional association of IRX4 with PC and its tumor suppressive effect. In prostate cancer diagnosis, neurotransmitter polypeptide neuropeptide-Y (NPY) had a potential as a prostate cancer biomarker polypeptide. We also found Terrestrosin D, a steroidal saponin from Tribulus terrestris L., inhibited growth and angiogenesis of prostate cancer in vitro and in vivo.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] D34(+) /CD38(-) acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells.2013
Author(s)
Nishioka C, Ikezoe T, Furihata M, Yang J, Serada S, Naka T, Nobumoto A, Kataoka S, Tsuda M, Udaka K, Yokoyama A
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Journal Title
International Journal of Cancer
Volume: 132(9)
Issue: 9
Pages: 2006-2019
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasma Low-Molecular-Weight Proteome Profiling Identified Neuropeptide-Y as a Prostate Cancer Biomarker Polypeptide2013
Author(s)
K. Ueda, A. Tatsuguchi, N. Saichi, A. Toyama, K. Tamura, M. Furihata, R. Takata, S. Akamatsu, M. Igarashi, M. Nakayama, T. A. Sato, O. Ogawa, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa
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Journal Title
Journal of proteome research
Volume: 12(10)
Issue: 10
Pages: 4497-4506
DOI
Related Report
Peer Reviewed
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