| Project/Area Number |
24590420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nara Medical University (2014)
University of Miyazaki (2012-2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今村 卓郎 宮崎大学, 医学部内科学講座, 准教授 (60203329)
佐藤 勇一郎 宮崎大学, 医学部病理学講座, 助教 (90347055)
鶴田 敏博 宮崎大学, 医学部内科学講座, 助教 (10389570)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 人体病理 / 循環器 / 動脈硬化 / 心筋梗塞 / 免疫染色 / 吸引血栓 / 組織病理学 / real time PCR / ヒトの病理組織標本 / 冠動脈プラーク / 病理組織学 / 血栓形成 / ポドプラニン / CLEC-2 / ポドプラ二ン / アテローム血栓症 / マクロファージ / 炎症 / Atherosclerosis / Thrombosis / Myocardial infarction / Histopathology / Immunohistochemistry |
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| Outline of Final Research Achievements |
Podoplanin/CLEC-2 is a platelet aggregation factor. In this study, the role of Podoplanin/CLEC-2 system in the pathogenesis of atherothrombosis was investigated. Using directional atherectomy(DCA) samples of angina pectoris patients(n=220), aspirated thrombi from coronary arteries of acute myocardial infarction(AMI) patients(n=100) and coronary arteries(n=60) from autopsy samples, we demonstrated that Podoplanin/CLEC-2 was overexpressed in the atherosclerotic lesions, and involved in the pathogenesis of atherothrombosis/acute coronary syndromes.
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