| Project/Area Number |
24590476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KITAGAWA Masanobu 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10177834)
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| Co-Investigator(Renkei-kenkyūsha) |
倉田 盛人 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (40451926)
阿部 晋也 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (70596725)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | MCM2 / アポトーシス / 腫瘍 / 治療モデル / 動物モデル / がん治療モデル / DNA損傷 / 治療 / モデル動物 |
|---|
| Outline of Final Research Achievements |
The interaction of viral proteins with host-cellular proteins elicits the activation of cellular signal transduction pathways. Previously, we have clarified that an infection with Friend leukemia virus (FLV) markedly enhanced the IR-induced apoptosis of hematopoietic cells in C3H mice in association with P53, ATM, and DNA-PK. The host specificity of this phenomenon was caused by the up-regulated expression of minichromosome maintenance (MCM) 2 in C3H mice. Furthermore, combined FLV and doxorubicin treatment extended the survival of SCID mice bearing MCM2-highly expressing 8047 leukemia cells.
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