the study about differentiation program of dendritic cells during malaria infection
| Project/Area Number |
24590507
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マラリア / 樹状細胞 |
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| Outline of Final Research Achievements |
The changes and mechanisms of number of splenic cDC and pDC after Plasmodium berghei ANKA (PbA) infection were analyzed. The number of cDC and pDC was significantly reduced after PbA infection. Further experiments demonstrate that type I and type II interferons were critically involved in activation and its-induced cell death of cDCs after PbA infection.
It is well known that individuals with repeated malaria infection have acquired immunity against parasites, but its mechanisms remain unclear. To investigate the changes of DC after malaria infection-cure treatment, mice infected with PbA were cured using pyrimethamine. The analysis about DC shows that splenic cDC significantly increased in cured mice.
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Report
(4 results)
Research Products
(3 results)
