the study about differentiation program of dendritic cells during malaria infection

Research Project

Project/Area Number	24590507
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Parasitology (including Sanitary zoology)
Research Institution	Kanazawa University
Principal Investigator	TAMURA Takahiko 金沢大学, 薬学系, 助教 (00434035)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	マラリア / 樹状細胞
Outline of Final Research Achievements	The changes and mechanisms of number of splenic cDC and pDC after Plasmodium berghei ANKA (PbA) infection were analyzed. The number of cDC and pDC was significantly reduced after PbA infection. Further experiments demonstrate that type I and type II interferons were critically involved in activation and its-induced cell death of cDCs after PbA infection. It is well known that individuals with repeated malaria infection have acquired immunity against parasites, but its mechanisms remain unclear. To investigate the changes of DC after malaria infection-cure treatment, mice infected with PbA were cured using pyrimethamine. The analysis about DC shows that splenic cDC significantly increased in cured mice.