Analyses of enteric bacterial products as a causative agent for the onset of intestinal amoebiasis
| Project/Area Number |
24590511
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 赤痢アメーバ / Bacteroides fragilis / 腸持続感染 / GalGalNAcレクチン / ペルオキシダーゼ / ミエロペルオキシダーゼ / CBA マウス / 腸持続感染モデル / Tritrichomonas foetus / Gal/GalAc lectin / B. fragilis 培養上清 / 増殖促進因子 / Entamoeba dispar / マウス腸持続感染モデル / virulence / 糖鎖 / Citrobacter freundii |
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| Outline of Final Research Achievements |
Promoting effects for the growth of Entamoeba histolytica, and for both persistent infections of E. histolytica and Tritrichomonas foetus to the cecum of CBA mouse were found in the culture supernatant of obligate anaerobic Bacteroides fragilis. Increase of corresponding sugar chains for GalGalNAc lectin of E. histolytica and inhibition of peroxidase activity were found by analyses of the culture supernatant. These bacterial metabolites have a possibility to affect to the onset of amoebiasis that has various conditions from latent to fulminant type.
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Identification of Entamoeba polecki with unique 18S rRNA gene sequences from Celebes crested macaques and pigs in Tangkoko Nature Reserve, North Sulawesi, Indonesia.2016
Author(s)
Tuda, J., Feng, M., Imada, M., Kobayashi, S., Cheng, X. and Tachibana, H.
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Journal Title
J. Euk. Microbiol.
Volume: 63
Issue: 5
Pages: 1-6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Species-specific immunity induced by infection with Entamoeba histolytica and Entamoeba moshkovskii in mice2013
Author(s)
Shimokawa, C., Culleton, R., Imai, T., Suzue, K., Hirai, M., Taniguchi, T., Kobayashi, S., Hisaeda, H., Hamano, S
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Journal Title
PLoS One
Volume: 8(11)
Issue: 11
Pages: e82025-e82025
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice2012
Author(s)
Shimokawa C, Kabir M, Taniuchi M, Mondal D, Kobayashi S, Ali IK, Sobuz SU, Senba M, Houpt E, Haque R, Petri WA Jr, Hamano S
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Journal Title
Infectious Diseases
Volume: 206
Pages: 744-751
Related Report
Peer Reviewed
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