| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Overall mortality with invasive pulmonary aspergillosis was over 50%, leading to strong expectation for development of a novel therapeutics. Aim of study is to elucidate correlation between cell cycle regulation and filamentous growth via analysis of protein kinases in Aspergillus fumigatus, the major causative agent of aspergillosis. I analyzed 8 protein kinases by inhibitors, gene disruption, gene downregulation, and chemical genetics. I found that Mps1 are essential for the growth. These results could contribute to basic research for a novel therapeutics of aspergillosis and give a new insight of unique mechanism for cell cycle regulation into basic biology field.
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