| Project/Area Number |
24590661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHASHI Kyoichi 大分大学, 副学長 (20137714)
IMAI Hiromitsu 大分大学, 医学部, 准教授 (30398250)
TSUTSUMI Kimiko 大分大学, 医学部, 助教 (20244171)
OHYAMA Tetsuji 大分大学, 医学部, 助教 (60574085)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 医薬品応答性 / 東アジア / 民族差 / 遺伝子多型 / 外的要因 / アジアにおける民族差 / 薬物動態 / 内的要因と外的要因 / 代謝酵素 / トランスポーター / 薬物トランスポーター / OATP / MRP4 / 国際情報交換 / 中国 / 韓国 |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate the effect of the genetic variations (intrinsic factor) of drug transporters, and the effect of food/drink (extrinsic factor) on drug disposition and response in Japanese, Korean and Chinese population. The results showed a marked effect of food/drink as compared to genetic variations. In addition, ethnic differences, which are difficult to be explained by genetic variations, were found. Further studies regarding extrinsic factors in relation to drug disposition and response are necessary.
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