| Project/Area Number |
24590664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
HOZUMI Isao 岐阜薬科大学, 薬学部, 教授 (20242430)
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| Co-Investigator(Kenkyū-buntansha) |
INUZUKA Takashi 岐阜大学, 大学院医学系研究科神経内科老年学分野, 教授 (50184734)
KUNISADA Takahiro 岐阜大学, 大学院医学系研究科組織・器官形成分野, 教授 (30255108)
國貞 隆弘 岐阜大学, 医学(系)研究科(研究院), 教授 (30205108)
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| Co-Investigator(Renkei-kenkyūsha) |
AKUTSU Hidenori 独立行政法人国立成育医療研究センター, 室長 (50347225)
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| Research Collaborator |
KANEKO Masayuki
INDEN Masatoshi
NOGUCHI Takao
ONO Hiroshi
IKEGAMI Saori
IRIYAMA Masaki
KUDO Daichi
IWASHITA Wakana
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経変性疾患 / iPS細胞 / メタロチオネイン / 筋萎縮性側索硬化症 / 分化誘導 / 創薬 |
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| Outline of Final Research Achievements |
We have been producing iPS cells from dentate pulp in the wisdom teeth and blood cells. We have been planning to treat amyotrophic lateral sclerosis (ALS)-model dogs with dental pulp stem cells. Metallothionine (MT) is a zinc- modulating protein and play important roles in the progression of ALS. In this study we have investigated also a zinc-modulating transporters ZnT families and found the decrease of ZnT-3 and ZnT-6, in particular in the spinal cords of the patients with ALS. This indicates that MT, ZnT-3 and ZnT-6 play pivotal roles in ALS. We have been revealing the roles of these proteins in ALS using iPS cells derived from ALS patients.
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