ANALYSIS OF THERAPEUTIC TARGET MOLECULES FOR ARRHYTHMIAS IN THE NEWLY DEVELOPED ANIMAL MODEL OF SUSTAINED ATRIAL FIBRILLATION
| Project/Area Number |
24590669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 心房細動 / 心房拡大 / 慢性容量負荷 / アルドステロン |
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| Outline of Final Research Achievements |
We assessed morphological and electrophysiological changes and duration of atrial fibrillation in rats with abdominal aortocaval fistula as a pathological model of chronic volume overload to the heart. In this animal model, increment of tissue weight of atrium, fibrosis, and decrement of mRNA levels of potassium channels and connexins were observed. Duration of atrial fibrillation induced by burst pacing in this animal model was longer than that in normal animals. Chronic administration of aldosterone to this animal model further increased duration of atrial fibrillation. Therefore, the study clarified that aldosterone in combination with morphological and electrophysiological changes induced by chronic volume overload to the heart potently promoted onset of atrial fibrillation.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Discovery and evaluation of selective N-type calcium channel blockers: 6-unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives.2012
Author(s)
Yamamoto T, Niwa S, Tokumasu M, Onishi T, Ohno S, Hagiwara M, Koganei H, Fujita S, Takeda T, Saitou Y, Iwayama S, Takahara A, Iwata S, Shoji M
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Journal Title
Bioorganic & Medicinal Chemistry Letters
Volume: 22
Issue: 11
Pages: 3639-3642
DOI
Related Report
Peer Reviewed
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[Presentation] 動静脈瘻ラット肺静脈心筋の電気生理学的性質2014
Author(s)
田中 愛弓, 恒岡 弥生, 鶴田 將人, 中山 貴弘, 灘 みづき, 相本 恵美, 濵口 正悟, 行方 衣由紀, 高原 章, 田中 光
Organizer
第130回日本薬理学会関東部会
Place of Presentation
星薬科大学（東京都品川区）
Year and Date
2014-07-05
Related Report
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[Presentation] Electrophysiological characteristics of atrial remodlings in the rat abdominal aortocaval fistula hypertrophy model.
Author(s)
八木 啓太, 江沢 亜耶, 福本 真理江, 恒岡 弥生, 濱口 正悟, 長谷川 健志, 久世 哲郎, 千葉 俊樹, 灘 みづき, 行方 衣由紀, 田中 光, 高原 章
Organizer
第86回日本薬理学会年会
Place of Presentation
福岡国際会議場（福岡県）
Related Report
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