Roles of glucocorticoid receptors in cardiac and adipose tissue pathology in a rat model of metabolic syndrome

• Project/Area Number: 24590690
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Nagoya University
• Principal Investigator: NAGATA Kohzo 名古屋大学, 医学(系)研究科(研究院), 教授 (20378227)
• Co-Investigator(Renkei-kenkyūsha): UEYAMA Jun 名古屋大学, 医学系研究科, 准教授 (00397465) ; HASHIMOTO Katsunori 名古屋大学, 医学系研究科, 助教 (70324423) ; ITO Hiromi 名古屋大学, 医学系研究科, 助教 (20610752)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: メタボリックシンドローム / ストレス / グルココルチコイド受容体 / βアドレナリン受容体 / 心筋傷害 / 脂肪組織炎症 / 糖代謝異常 / メタボリック症候群 / 高血圧 / 心筋リモデリング / 左室拡張障害 / 脂肪組織 / グルココルチコイド / 酸化ストレス / 炎症

Research Abstract

We first clarified the pathophysiological roles of the glucocorticoid-glucocorticoid receptor (GR) axis in cardiac and adipose tissue pathology of DahlS.Z-Leprfa/Leprfa (DS/obese) rats as a new animal model of metabolic syndrome (MetS). We next investigated the responses to cold stress and restraint stress in these rats. Cold stress and the GR blocker RU486 did not affect obesity in DS/obese rats. In contrast, restraint stress to DS/obese rats attenuated obesity in a manner sensitive to the beta-adrenergic receptor blocker propranolol. Both types of stress exacerbated hypertension, cardiac injury, adipose tissue inflammation, and glucose metabolism, and all of these effects were ameliorated by RU486 with cold stress and by propranolol with restraint stress.

Research Products

• [Presentation] Glucocorticoid receptor blockade ameliorates cold stress-induced exacerbation of cardiac and adipose tissue pathology in a rat model of metabolic syndrome (2014)
  • Author(s): Kai Nagasawa, Natsumi Matsuura, Yuji Minagawa, Yuuri Takeshita, Sae Ohura, Takuya Hattori, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Restraint stress attenuates obesity and deteriorates cardiac and adipose tissue pathology viaβ-adrenergic receptors in rats with metabolic syndrome (2014)
  • Author(s): Natsumi Matsuura, Kai Nagasawa, Yuji Minagawa, Sae Ohura, Yuuri Takeshita, Takuya Hattori, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Restraint stress attenuates obesity and deteriorates cardiac and adipose tissue pathology via β-adrenergic receptors in rats with metabolic syndrome (2014)
  • Author(s): Natsumi Matsuura, Kai Nagasawa, Yuji Minagawa, Sae Ohura, Yuuri Takeshita, Takuya Hattori, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] RU486を用いたグルココルチコイド受容体遮断はメタボリックシンドロームラットの脂肪組織炎症と心筋傷害を軽減する (2013)
  • Author(s): 竹下侑里、高橋圭司、大浦彩依、松浦菜摘、長澤快、服部拓哉、渡辺彰吾、伊藤裕美、室原豊明、永田浩三
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
• [Remarks]
  • URL: http://nagata-lab.jimdo.com/