| Project/Area Number |
24590700
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
TANAKA MAKI 札幌医科大学, 医学部, 助教 (40207139)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI SATOSHI 札幌医科大学, 医学部, 教授 (30332919)
KOBAYASHI DAISUKE 札幌医科大学, 医学部, 講師 (50295359)
WATANABE NAOKI 札幌医科大学, 医学部, 名誉教授 (10158644)
KURIBAYASHI KAGEAKI 札幌医科大学, 医学部, 講師 (50381257)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Stanniocalcin-1 / NADPH オキシターゼ / 乳癌 / 転移能 / 浸潤能 / Stanniocalcin / stanniocalcin / NADPH oxidase |
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| Outline of Final Research Achievements |
In this study, we aimed to evaluate potential marker of metastasis in breast cancer. Reactive oxygen species, produced from NADPH oxidase (NOX), affect cancer metastasis and accelerate cell migration. Stanniocalcin-1 (STC-1), a regulator of calcium metabolism, is highly expressed in tumor cells. Therefore, we focused our research on calcium-dependent NOX5 and STC-1 molecules. High levels of STC-1 in breast cancer cells accelerated cell motility and enhanced lung metastasis in mice. However, no difference in cell migration was observed with high levels of NOX5. Thus, we conclude that STC-1 enhances the metastatic potential of breast cancer cells and our results suggest that STC-1 may have utility as a novel prediction marker of metastasis.
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